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This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for peopl
by pitpatagain 1y ago
This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.
- kjkjadksj 1y agoPeople on ozempic certainly look more like the crypt keeper than a younger version of themselves. You lose all that buccal fat that defines your young adult face.
- radiofreeeuropa 1y agoAny means of attaining weight loss at a similar rate will tend to do the same thing. Especially if you’re starting from quite-heavy, not just dropping 20lb or something.
- YokoZar 1y agoIt varies. People are often thinner in their twenties than their thirties and forties. If you browse some before and after pictures the ones who have had their skin tighten tend to look younger for that reason alone.
- kjkjadksj 1y agoEven naturally thin people have buccal fat and healthy looking cheek and jawlines.
- pitpatagain 1y agoOr that's who you notice. My husband takes ozempic for type 2 diabetes and it completely fixed his blood sugar while causing very moderate weight loss. What the people in this study have causes abnormal visceral fat accumulation in the belly and back and itself causes disturbing changes in body shape and appearance, does not respond or normal weight loss, and hasn't had real treatment options. That ozempic has beneficial effects for it in an RCT is actually awesome, it's the framing given by the headline that is bad.
- angmarsbane 1y agoI notice it in people who have never been the weight that they're suddenly walking around as, with them it often looks overdone, too thin for their features etc, but in those who have used it to get back to weights where I've seen them before...I didn't guess. They had to tell me.
- const_cast 1y agoThat's just what happens when you get skinny. People who have always been skinny just look sickly always so we don't notice.
- saberience 1y agoI've always been naturally slim and people my whole life have been telling me I look 10-15 years younger than my actual age... the "Ozempic face" is a totally different look, it makes you look gaunt and dying.
- const_cast 1y agoThis is just not true, and as I've stated, it's because you've always been skinny. There's no magic sauce in ozempic that makes you lose more buccal fat than other weight loss methods. That's just not real, it doesn't exist. When you go from lots of buccal fat to no buccal fat, you will look gaunt in comparison. You've always had low fat so there's no frame of reference, so nobody calls you gaunt. But, if you gained say 30 pounds, you would look much less gaunt than you currently do. Either that or you're not as slim as you think you are. At 5'9 a normal BMI sits at 135 pounds for a man - you need to get very thin to have thin cheeks. Its possible you're slim, but not slim enough to have slim cheeks. Also you lose buccal fat as you age. But ozempic does not age you. And then of course fat distribution varies person to person. You might be slim but have abnormally large amounts of buccal fat. That can happen, but it doesn't mean that if you got thin via ozempic you'd lose the buccal fat. Again, there's no mechanism for that. If you still don't believe me, just compare someone thin via ozempic versus someone naturally thin at the exact same weight and height and gender. Notice the buccal fat - the naturally thin person doesn't have more. It just feels that way, because you've never seen them with more buccal fat so the amount they have seems "right". Whereas, for the ozempic person, it seems less.
- fc417fc802 1y agoYou're dismissing a claimed observation without evidence. I have no horse in this race but I'll comment that you appear to be attempting to claim that there's no difference between "skinny" and "crypt keeper". That's a preposterous position to take. The various terminology exists because people use it to describe real world differences. For example skinny, gangly, and gaunt aren't the same thing (although there is often significant overlap).
- wonderwonder 1y agoI agree, I'm 46. I dropped from 240lbs in January to 209lbs in June. I have maintained that weight. Recently went to a beach resort for a vacation and the number of random people that commented on my build was embarrassing. From bar tenders making a point of serving me first and asking me how much I benched to the literal wives of other men saying "Hi Vin Diesel" (3 times) in front of their husbands and my wife. I have a shaved head and tan so its going to always be Vin Diesel or the Rock. My wife even commented that people keep staring at me. I literally realized how amazing life must be for a hot girl. Must have been because of how disgusting I look... I think you may be making things up to make yourself feel better friend.
- koliber 1y agoPeople who lose a lot of fat generally end up with loose skin, regardless of the mechanism they use to lose the fat.
- JumpCrisscross 1y ago> lose all that buccal fat that defines your young adult face The people who should be taking Ozempic aren't lacking in buccal fat.
- kjkjadksj 1y agoSure. But plenty of seemingly not fat people take it which is when things go awry with the gaunt look imo. Lots of celebs in their 30s 40s 50s with transformed skin on bone faces as a result of this stuff.
- cthalupa 1y agoI've dropped about 1/3rd of my bodyweight on retatrutide. The 2nd most common comment I receive is that I look 5+ years younger.
- elzbardico 1y agoLosing facial fat will only make you look older if your skin has low elasticity and/or if you lose too much fat, too much fast. Also, it is very common for people that start eating dramatically less to also reduce their water intake too much and become dehydrated. Besides ensuring you're getting sufficient water, there are a lot of dermatologic procedures that can help you to recover at least some of your skin elasticity. And in more dramatic cases, there's a plethora of options, from fillers to lifting procedures.
- kjkjadksj 1y agoFillers and facelifts also look bad and don’t last
- elzbardico 1y agoNonsense. Most procedures have excellent results if done by a skilled professional. And yes, things don't last forever, news at 11.
- leoh 1y agoTrue enough, but many studies show that calorie restriction reduces effects of aging
- radu_floricica 1y agoNot really applicable in humans. Effect is smaller than in mice, and requires some pretty drastic restrictions that aren't exactly pleasant. The thing with ozempic is that is seems to do several things, most (all?) of them good for us in different ways. We probably just lucked out. It's not the only case - plenty of drugs do incredibly good things with only reasonable side effects. Antibiotics. Ibuprofen. Aspirin. Vitamin D. A recent example - statins used to be seen as a tradeoff: you get better cardiovascular health, but some hepatotoxicity. Nope, it was wrong - they actually protect your liver. I think the official change came out this year, when I started them a couple of years ago I still found it framed as a side effect.
- rybosworld 1y agoCan you say more about Ibuprofen? I've understood it's fairly dangerous in some contexts. Especially for folks with compromised liver function.
- amy214 1y agotylenol is the one that's hepatotoxic (spanish for harmful to the liver) - ibuprofen is nephrotoxic (italian for harmful to the kidney) maybe you are mixing up your very similar painkillers. in kiddos it's common to go back and forth between them for pain control, thusly attenuating specific insult to liver or kidney. then there's aspirin, don't give that to kids, that's a whole thing
- simmerup 1y agoStatins change some peoples personalities https://www.bbc.co.uk/future/article/20200108-the-medications-that-change-who-we-are https://www.bbc.co.uk/future/article/20200108-the-medication...
- dwroberts 1y agoThey address this and state that there is no reason to believe it wouldn’t also apply to the general population who do not have lipohypertrophy
- GenBiot 1y agoHowever they have no evidence of this. While I would expect this to be the case (as a researcher of ageing epigenetics), this is entirely conjecture.
- RataNova 1y agoThe underlying mechanisms (reduced inflammation, improved fat distribution, better metabolic health) aren't unique to that group
- tomxor 1y ago> The underlying mechanisms (reduced inflammation, improved fat distribution, better metabolic health) aren't unique to that group Those are causes, you can't just invert it (again) and call them mechanisms for anti-aging... Those things are side effects of obesity and diseases causing obesity, there is no evidence or reasonable basis here to suggest there would be any "anti-aging" effect in healthy people without those problems. Similarly "Ozempic shows anti-gravity effect in humans!#11"... assuming you have unhealthy excess fat to lose.
- cthalupa 1y agoExcept the post they responded to specifically called out HIV-associated lipohypertrophy and the post you are responding to pointed out that the issues being tackled are not unique to HIV-associated lipohypertrophy. More than 70% of Americans are overweight. That's a pretty overwhelming majority. Most of the Western world and significant portions of the Eastern world are trending in the same direction. The point is that this can be generalized to a whole lot of people, not just those with HIV. And there are other causes of inflammation besides just being overweight, and the GLP-1s reduce inflammation basically immediately, even with no weight loss.
- deleted 1y ago[deleted]
- edmundsauto 1y agoCause and effect in the body are intertwined with some very clear and mostly not understood feedback and feedforward loops.