6 ms·

...IN MICE

mlhpdx 2y ago
And not just mice, but mice engineered with “T1D like” conditions. Human testing too early is certainly undesirable but these studies with mice, while necessary and important, are nothing newsworthy for the general public (but good for fundraising for follow up work).
_carbyau_ 2y ago
Yeah! How amazing is that! Reversing type 1 diabetes anywhere is amazing. A way to go until it becomes an option for humans. And then way more to go until it becomes a preferred option. But this is great news.
- jfengel 2y ago
  Not if it requires immune suppressants. They can already transplant whole pancreases. They rarely do because the resulting lifetime of immune suppression is worse than the quite effective insulin injections. Any research could pay big benefits eventually but this is far from "great news". It's a step forward along a path that is actually well behind the others.
  - _carbyau_ 2y ago
    I think you and I have a different approach to science. I see research as not entirely linear and think that multiple paths should be funded. Most paths won't be "the definitive answer" but add capability, or definitively rule out an approach, that can be used in other scenarios. TheFineArticle shows a different path to the others and they made a great step on it - that seems like money well spent to me. What I get from reading your post is that it's some kind of race and only the one currently winning should be lauded. I'm not sure if that is what you intend to communicate though.
  - energy123 2y ago
    Rapamycin increases lifespan of mice more than any other known compound.
    - nahsra 2y ago
      Longevity benefits are seen at a much lower dose. https://en.m.wikipedia.org/wiki/The_dose_makes_the_poison https://en.m.wikipedia.org/wiki/The_dose_makes_the_poison
bitwize 2y ago
Late last year a woman's T1D was put into remission using beta cells derived from her own stem cells: https://www.nature.com/articles/s41591-024-03394-9 https://www.nature.com/articles/s41591-024-03394-9 She was on immunosuppressants, so how long the new beta cells would last without those is still an open question. Other similar, ongoing trials are showing promising results.
strkitten 2y ago
Indeed, I would appreciate if the title were updated to reflect that the subjects were mice, not humans. It’s a bit misleading.

...IN MICE

And not just mice, but mice engineered with “T1D like” conditions. Human testing too early is certainly undesirable but these studies with mice, while necessary and important, are nothing newsworthy for the general public (but good for fundraising for follow up work).

_carbyau_ 2y ago

Yeah! How amazing is that! Reversing type 1 diabetes anywhere is amazing. A way to go until it becomes an option for humans. And then way more to go until it becomes a preferred option. But this is great news.

jfengel 2y ago
Not if it requires immune suppressants. They can already transplant whole pancreases. They rarely do because the resulting lifetime of immune suppression is worse than the quite effective insulin injections. Any research could pay big benefits eventually but this is far from "great news". It's a step forward along a path that is actually well behind the others.
- _carbyau_ 2y ago
  I think you and I have a different approach to science. I see research as not entirely linear and think that multiple paths should be funded. Most paths won't be "the definitive answer" but add capability, or definitively rule out an approach, that can be used in other scenarios. TheFineArticle shows a different path to the others and they made a great step on it - that seems like money well spent to me. What I get from reading your post is that it's some kind of race and only the one currently winning should be lauded. I'm not sure if that is what you intend to communicate though.
- energy123 2y ago
  Rapamycin increases lifespan of mice more than any other known compound.
  - nahsra 2y ago
    Longevity benefits are seen at a much lower dose. https://en.m.wikipedia.org/wiki/The_dose_makes_the_poison https://en.m.wikipedia.org/wiki/The_dose_makes_the_poison

bitwize 2y ago

Late last year a woman's T1D was put into remission using beta cells derived from her own stem cells: https://www.nature.com/articles/s41591-024-03394-9 https://www.nature.com/articles/s41591-024-03394-9 She was on immunosuppressants, so how long the new beta cells would last without those is still an open question. Other similar, ongoing trials are showing promising results.

strkitten 2y ago

Indeed, I would appreciate if the title were updated to reflect that the subjects were mice, not humans. It’s a bit misleading.