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Folding@home uses Rosetta, a physics-based approach that is outperformed by deep learning methods such as AlphaFold2/3.
by EdHarris 2y ago
Folding@home uses Rosetta, a physics-based approach that is outperformed by deep learning methods such as AlphaFold2/3.
- flobosg 2y agoFolding@home uses Rosetta only to generate initial conformations[1], but the actual simulation is based on Markov State Models. Note that there is another distributed computing project for Rosetta, Rosetta@home. [1]: https://foldingathome.org/dig-deeper/#:~:text=employing%20Rosetta%E2%80%99s%20Monte%20Carlo%20algorithm https://foldingathome.org/dig-deeper/#:~:text=employing%20Ro...