4 ms·

Anybody know why MRNA cancer vaccines didn't work out? seems like it's almost the same methodology in making the immune system target specific proteins.

garbageman 2y ago
They might but if I recall MRNA stuff is pretty new - and getting the clinical trials through the entire process and approval takes quite a long time.
vondur 2y ago
Looks like doctors were able to treat brain cancer with a mRNA derived vaccine: https://ufhealth.org/news/2024/uf-developed-mrna-vaccine-triggers-fierce-immune-response-to-fight-malignant-brain-tumor https://ufhealth.org/news/2024/uf-developed-mrna-vaccine-tri...
jsperx 2y ago
As somebody who unfortunately has a Stage IV diagnosis I have been researching mRNA and there have been promising results such as the MSK pancreatic study below, but still much to be ironed out — they had half the participants get a response but the other half nothing, even though each treatment was individually targeted and customized. They are doing a larger study now to try to see what other factors may be at play. https://www.mskcc.org/news/can-mrna-vaccines-fight-pancreatic-cancer-msk-clinical-researchers-are-trying-find-out https://www.mskcc.org/news/can-mrna-vaccines-fight-pancreati...
adamredwoods 2y ago
mRNA vaccines need a target, and if there is a target, there are several approaches that already do this (anti-body drug conjugates), and sometimes work, sometimes doesn't. I don't think anybody thinks it "didn't work out". It's still actively ongoing: https://www.mdanderson.org/newsroom/md-anderson-curevac-enter-strategic-collaboration-develop-novel-cancer-vaccines.h00-159696756.html https://www.mdanderson.org/newsroom/md-anderson-curevac-ente... https://investors.modernatx.com/news/news-details/2023/Moderna-and-Merck-Announce-mRNA-4157V940-an-Investigational-Personalized-mRNA-Cancer-Vaccine-in-Combination-With-KEYTRUDAR-pembrolizumab-was-Granted-Breakthrough-Therapy-Designation-by-the-FDA-for-Adjuvant-Treatment-of-Patients-With-High-Risk-Melanom/default.aspx https://investors.modernatx.com/news/news-details/2023/Moder... (from 2021): https://link.springer.com/article/10.1186/s12943-021-01348-0/tables/1 https://link.springer.com/article/10.1186/s12943-021-01348-0... https://link.springer.com/article/10.1186/s12943-021-01348-0 https://link.springer.com/article/10.1186/s12943-021-01348-0
mcbain 2y ago
One big trial still going: https://clinicaltrials.gov/study/NCT03739931 https://clinicaltrials.gov/study/NCT03739931
rafaelero 2y ago
They do work, mainly for keeping a remissed cancer at bay.

garbageman 2y ago

They might but if I recall MRNA stuff is pretty new - and getting the clinical trials through the entire process and approval takes quite a long time.

vondur 2y ago

Looks like doctors were able to treat brain cancer with a mRNA derived vaccine: https://ufhealth.org/news/2024/uf-developed-mrna-vaccine-triggers-fierce-immune-response-to-fight-malignant-brain-tumor https://ufhealth.org/news/2024/uf-developed-mrna-vaccine-tri...

jsperx 2y ago

As somebody who unfortunately has a Stage IV diagnosis I have been researching mRNA and there have been promising results such as the MSK pancreatic study below, but still much to be ironed out — they had half the participants get a response but the other half nothing, even though each treatment was individually targeted and customized. They are doing a larger study now to try to see what other factors may be at play. https://www.mskcc.org/news/can-mrna-vaccines-fight-pancreatic-cancer-msk-clinical-researchers-are-trying-find-out https://www.mskcc.org/news/can-mrna-vaccines-fight-pancreati...

adamredwoods 2y ago

mRNA vaccines need a target, and if there is a target, there are several approaches that already do this (anti-body drug conjugates), and sometimes work, sometimes doesn't. I don't think anybody thinks it "didn't work out". It's still actively ongoing: https://www.mdanderson.org/newsroom/md-anderson-curevac-enter-strategic-collaboration-develop-novel-cancer-vaccines.h00-159696756.html https://www.mdanderson.org/newsroom/md-anderson-curevac-ente... https://investors.modernatx.com/news/news-details/2023/Moderna-and-Merck-Announce-mRNA-4157V940-an-Investigational-Personalized-mRNA-Cancer-Vaccine-in-Combination-With-KEYTRUDAR-pembrolizumab-was-Granted-Breakthrough-Therapy-Designation-by-the-FDA-for-Adjuvant-Treatment-of-Patients-With-High-Risk-Melanom/default.aspx https://investors.modernatx.com/news/news-details/2023/Moder... (from 2021): https://link.springer.com/article/10.1186/s12943-021-01348-0/tables/1 https://link.springer.com/article/10.1186/s12943-021-01348-0... https://link.springer.com/article/10.1186/s12943-021-01348-0 https://link.springer.com/article/10.1186/s12943-021-01348-0

mcbain 2y ago

One big trial still going: https://clinicaltrials.gov/study/NCT03739931 https://clinicaltrials.gov/study/NCT03739931

rafaelero 2y ago

They do work, mainly for keeping a remissed cancer at bay.