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How about HSV-1/2? Combined this virus is present in about 2/3 people in the US, and resides dormant near the brain (with cold sores). I thought there's alread

How about HSV-1/2? Combined this virus is present in about 2/3 people in the US, and resides dormant near the brain (with cold sores). I thought there's already a strong link with HSV and Dementia, is there any more research looking at this virus and a vaccine?

untilHellbanned 3y ago
Yes Ruth Itzaki has been talking about this for years. https://www.beingpatient.com/ruth-itzhaki-alzheimers-viruses/ https://www.beingpatient.com/ruth-itzhaki-alzheimers-viruses... Potential Rosalind Franklin scenario. https://www.healthspan.dev https://www.healthspan.dev is making a mRNA vaccine. Sam Altman funded company.
- toomuchtodo 3y ago
  Not going to be surprised if the most common viruses are what leads to cancer and mRNA is what becomes a cancer preventative as protocols ramp against said viruses. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994798/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994798/ > An estimated 15 percent of all human cancers worldwide may be attributed to viruses, representing a significant portion of the global cancer burden. Both DNA and RNA viruses have been shown to be capable of causing cancer in humans. Epstein-Barr virus, human papilloma virus, hepatitis B virus, and human herpes virus-8 are the four DNA viruses that are capable of causing the development of human cancers. Human T lymphotrophic virus type 1 and hepatitis C viruses are the two RNA viruses that contribute to human cancers. https://pubmed.ncbi.nlm.nih.gov/25083895/ https://pubmed.ncbi.nlm.nih.gov/25083895/ Kudos to anyone accelerating mRNA in this space.
  - epicureanideal 3y ago
    But why mRNA specifically instead of a protein or other vaccine? What’s the advantage?
    - adgjlsfhk1 3y ago
      mrna vaccines are a lot harder for viruses to mutate away from (and easier to adapt if they do) because they let you target a gene sequence directly.
      - dbsights 3y ago
        That doesn't really make sense. Target specifically, and it only takes a minor mutation to escape. A less-specific vaccine would create immunity against multiple targets, and would logically require more simultaneous mutations to create an escape variant. Unless your goal is to sell a new vaccine every year (chase your own escape variants, immunity-as-a-service), then MRNA isn't obviously a win.
        2fast4you 3y ago
        Not an expert, but couldn’t the mRNA vaccine target only part of the virus genome that’s stable across mutations/variants? That would give you a broad vaccine resistant to mutations
        dbsights 3y ago
        Stable across mutations? On what timeframe.. Its been stable so far. However, create a population with narrow immunity based on a single protein, and you create a selection pressure that incentivizes mutations in that protein. Once a successful mutation exists, it has a wide open field to spread unchecked. With broad immunity (multiple proteins) it is much less likely that a variant can realize the multiple simultaneous mutations that would be required to spread effectively.
        bsder 3y ago
        > Target specifically, and it only takes a minor mutation to escape. 1) Not all sections of a virus mutate at the same rate. Some sections of a virus are highly conserved or the virus simply dies. In Covid-19, for example, the spike protein seems to be difficult to change significantly as it provides the primary entry for the virus into cells. 2) mRNA vaccines tell your immune system "target this specific sequence" and can avoid problematic sequences. Normally, you have no idea what section of the virus your immune system locked onto. Even worse, if your immune system grabs onto something common (EBV pieces causing MS or alpha-gal from a tick bite, for example), it can hose you bad.
- lifty 3y ago
  do you know if this vaccine will work for existing dormant infections?
foolfoolz 3y ago
there’s quite a bit of active HSV1/2 work being done although it’s very early stage. a few vaccines. a cure attempt. unfortunately this virus is not seen as a target for funding. some of the labs working on these are just sub-teams of larger companies working to fight other medical challenges such as HIV or cancer. those get the funding and they are able to set side some money for HSV research. probably because it’s thought of as a simple skin virus when more likely it’s a nervous system virus that manifests most visibly in the skin
- CommanderData 3y ago
  Even if there were a strong link between HSV and Dementia, I don't believe our governments would fast track or fund such research because their priorities. It would be nice if Gates or Elon Musk would bring the worlds attention to these issues and if something positive comes out of it would be a massive net positive to humanity.
  - foolfoolz 3y ago
    priorities are pretty clear. we spent <$20B on the covid vaccine, operation warp speed. ukraine received $75B in the last year from the u. s. if it was the same price, we could have solved 4 highly infectious diseases in just the last year. i’m not trying to get political on that specific war; just military in general is where the money goes
    - readthenotes1 3y ago
      Well, the US spends far more on elder care than on the military, so you should say that that is where the money goes. https://en.m.wikipedia.org/wiki/Expenditures_in_the_United_States_federal_budget https://en.m.wikipedia.org/wiki/Expenditures_in_the_United_S...
    - hedora 3y ago
      Imagine if, after the first oil crisis, the US had earmarked 10% of the military’s middle east budget to R&D for energy independence. We would have solved the global warming problem by the mid 1990’s.

untilHellbanned 3y ago

Yes Ruth Itzaki has been talking about this for years. https://www.beingpatient.com/ruth-itzhaki-alzheimers-viruses/ https://www.beingpatient.com/ruth-itzhaki-alzheimers-viruses... Potential Rosalind Franklin scenario. https://www.healthspan.dev https://www.healthspan.dev is making a mRNA vaccine. Sam Altman funded company.

toomuchtodo 3y ago
Not going to be surprised if the most common viruses are what leads to cancer and mRNA is what becomes a cancer preventative as protocols ramp against said viruses. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994798/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994798/ > An estimated 15 percent of all human cancers worldwide may be attributed to viruses, representing a significant portion of the global cancer burden. Both DNA and RNA viruses have been shown to be capable of causing cancer in humans. Epstein-Barr virus, human papilloma virus, hepatitis B virus, and human herpes virus-8 are the four DNA viruses that are capable of causing the development of human cancers. Human T lymphotrophic virus type 1 and hepatitis C viruses are the two RNA viruses that contribute to human cancers. https://pubmed.ncbi.nlm.nih.gov/25083895/ https://pubmed.ncbi.nlm.nih.gov/25083895/ Kudos to anyone accelerating mRNA in this space.
- epicureanideal 3y ago
  But why mRNA specifically instead of a protein or other vaccine? What’s the advantage?
  - adgjlsfhk1 3y ago
    mrna vaccines are a lot harder for viruses to mutate away from (and easier to adapt if they do) because they let you target a gene sequence directly.
    - dbsights 3y ago
      That doesn't really make sense. Target specifically, and it only takes a minor mutation to escape. A less-specific vaccine would create immunity against multiple targets, and would logically require more simultaneous mutations to create an escape variant. Unless your goal is to sell a new vaccine every year (chase your own escape variants, immunity-as-a-service), then MRNA isn't obviously a win.
      - 2fast4you 3y ago
        Not an expert, but couldn’t the mRNA vaccine target only part of the virus genome that’s stable across mutations/variants? That would give you a broad vaccine resistant to mutations
        dbsights 3y ago
        Stable across mutations? On what timeframe.. Its been stable so far. However, create a population with narrow immunity based on a single protein, and you create a selection pressure that incentivizes mutations in that protein. Once a successful mutation exists, it has a wide open field to spread unchecked. With broad immunity (multiple proteins) it is much less likely that a variant can realize the multiple simultaneous mutations that would be required to spread effectively.
      - bsder 3y ago
        > Target specifically, and it only takes a minor mutation to escape. 1) Not all sections of a virus mutate at the same rate. Some sections of a virus are highly conserved or the virus simply dies. In Covid-19, for example, the spike protein seems to be difficult to change significantly as it provides the primary entry for the virus into cells. 2) mRNA vaccines tell your immune system "target this specific sequence" and can avoid problematic sequences. Normally, you have no idea what section of the virus your immune system locked onto. Even worse, if your immune system grabs onto something common (EBV pieces causing MS or alpha-gal from a tick bite, for example), it can hose you bad.
lifty 3y ago
do you know if this vaccine will work for existing dormant infections?

foolfoolz 3y ago

there’s quite a bit of active HSV1/2 work being done although it’s very early stage. a few vaccines. a cure attempt. unfortunately this virus is not seen as a target for funding. some of the labs working on these are just sub-teams of larger companies working to fight other medical challenges such as HIV or cancer. those get the funding and they are able to set side some money for HSV research. probably because it’s thought of as a simple skin virus when more likely it’s a nervous system virus that manifests most visibly in the skin

CommanderData 3y ago
Even if there were a strong link between HSV and Dementia, I don't believe our governments would fast track or fund such research because their priorities. It would be nice if Gates or Elon Musk would bring the worlds attention to these issues and if something positive comes out of it would be a massive net positive to humanity.
- foolfoolz 3y ago
  priorities are pretty clear. we spent <$20B on the covid vaccine, operation warp speed. ukraine received $75B in the last year from the u. s. if it was the same price, we could have solved 4 highly infectious diseases in just the last year. i’m not trying to get political on that specific war; just military in general is where the money goes
  - readthenotes1 3y ago
    Well, the US spends far more on elder care than on the military, so you should say that that is where the money goes. https://en.m.wikipedia.org/wiki/Expenditures_in_the_United_States_federal_budget https://en.m.wikipedia.org/wiki/Expenditures_in_the_United_S...
  - hedora 3y ago
    Imagine if, after the first oil crisis, the US had earmarked 10% of the military’s middle east budget to R&D for energy independence. We would have solved the global warming problem by the mid 1990’s.