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Twitter thread from a vaccine developer: https://threadreaderapp.com/thread/1464222680731820043.html https://threadreaderapp.com/thread/1464222680731820043.html

Twitter thread from a vaccine developer: https://threadreaderapp.com/thread/1464222680731820043.html https://threadreaderapp.com/thread/1464222680731820043.html A lot of speculation still, but it's not all bad so far.

sour-taste 5y ago
What an atrocious ad filled useless site. Original thread here: https://twitter.com/sailorrooscout/status/1464222680731820043 https://twitter.com/sailorrooscout/status/146422268073182004...
- malepoon 5y ago
  Thanks. At some point Twitter itself didn't let you read threads without logging in, but it looks like they changed that...
nostromo 5y ago
This image really puts it in context: https://images.app.goo.gl/13amCWF8aJ8q2eZAA https://images.app.goo.gl/13amCWF8aJ8q2eZAA The red portion of the graph on the far right is the new variant.
- tigershark 5y ago
  It started from an extremely low base. And extrapolating that curve is completely wrong as you can see from today numbers. 2.8k compared to yesterday 2.4K. It’s obviously still early to know anything conclusive but the relatively small increase today is a very good sign. We’ll know something more next week.
  - dillondoyle 5y ago
    https://imgs.xkcd.com/comics/extrapolating.png https://imgs.xkcd.com/comics/extrapolating.png
- sharken 5y ago
  To further put things into perspective, here the daily number of infections have gone from a few hundred up to 5.000. And this was before Omicron was known.
reindeer76 5y ago
>vaccine developer >Chair of ...Maryland's Newest Anthropomorphic Convention! Not sure how I feel about this. Are many vaccine developers also furries?
- mdni007 5y ago
  And he's a scientist but believes in horoscopes. I don't think I've seen someone living a more hypocritical lifestyle
  - PicassoCTs 5y ago
    https://webapp1.dlib.indiana.edu/newton/project/about.do https://webapp1.dlib.indiana.edu/newton/project/about.do Its actually pretty common to venture outside the box in every regard, if you have the ability to venture outside the box.
    - ASalazarMX 5y ago
      But horoscopes, my god. They're not outside the box, they're outside reality. It's like a physicist believing in perpetual motion.
      - tedunangst 5y ago
        But they're a biologist? Cosmic forces are outside their field, unlike a physicist who believes in perpetual motion.
        ASalazarMX 5y ago
        Biologists have to know statistics. Horoscopes are evidently impossible to anyone who knows basic statistics, if the generic fortunes weren't evident enough.
        tedunangst 5y ago
        Are they? If the newspaper says Pisces is going to have a good day and Libra is going to have a bad day, I feel I'd have to ask way more people than I'm likely to meet to determine whether it's true or not. I don't know why you'd say it's evidently impossible.
koheripbal 5y ago
His argument is fallacious. He's saying that since there all other variants we're susceptible to the vaccine, it's unlikely that this one is. ...and goes on to list the high number of different markers the vaccines target. Unfortunately, vaccines largely target the spike proteins, and sequencing of omicron is demonstrating that every single protein marker on the spike is changed. Vaccines will likely have a very small effect on this variant. There are also two other mutations of concern that have never been seen together that each increase binding to ACE2 for cell entry. This all needs to be formally confirmed, but this is probably BAD.
- fartattack 5y ago
  Your argument is fallacious. You clearly lack even an elementary education in immunology. Exposure to the antigen teaches your immune memory cells what the antigen looks like. Quit your job, stay home, live in fear. The rest of society doesn't need cowards like you. The pandemic is over, except for paranoid people. There will be endless variants. It's an RNA virus. No amount of vaccination will be perfect, but life will go on. Get vaccinated and go expose yourself to the existing endemic variants; it's the best defense there is. Live your life. If you think you can wait until there are no more variants, you'll be locked inside wearing a mask forever. Some of us have lives to lead.
- Kye 5y ago
  Chise is a she/her-shaped creature as far as I know.
- op00to 5y ago
  No. If every single “protein marker” on the spike protein was changed, there wouldn’t be a heck of a lot of chance for the virus to attach to a cell. There still needs to be basic compatibility with the cell and the spike to get inside.
  - chii 5y ago
    > there wouldn’t be a heck of a lot of chance for the virus to attach to a cell. but there isn't just a single shape that could be used to attach to a cell. Another shape could be compatible, but is not targeted by the vaccine of today. I'm guessing that this makes the virus a different virus - but isn't that what mutations are? they are slowly causing the virus to change and at some point, it becomes a different virus.

sour-taste 5y ago

What an atrocious ad filled useless site. Original thread here: https://twitter.com/sailorrooscout/status/1464222680731820043 https://twitter.com/sailorrooscout/status/146422268073182004...

malepoon 5y ago
Thanks. At some point Twitter itself didn't let you read threads without logging in, but it looks like they changed that...

nostromo 5y ago

This image really puts it in context: https://images.app.goo.gl/13amCWF8aJ8q2eZAA https://images.app.goo.gl/13amCWF8aJ8q2eZAA The red portion of the graph on the far right is the new variant.

tigershark 5y ago
It started from an extremely low base. And extrapolating that curve is completely wrong as you can see from today numbers. 2.8k compared to yesterday 2.4K. It’s obviously still early to know anything conclusive but the relatively small increase today is a very good sign. We’ll know something more next week.
- dillondoyle 5y ago
  https://imgs.xkcd.com/comics/extrapolating.png https://imgs.xkcd.com/comics/extrapolating.png
sharken 5y ago
To further put things into perspective, here the daily number of infections have gone from a few hundred up to 5.000. And this was before Omicron was known.

reindeer76 5y ago

>vaccine developer >Chair of ...Maryland's Newest Anthropomorphic Convention! Not sure how I feel about this. Are many vaccine developers also furries?

mdni007 5y ago
And he's a scientist but believes in horoscopes. I don't think I've seen someone living a more hypocritical lifestyle
- PicassoCTs 5y ago
  https://webapp1.dlib.indiana.edu/newton/project/about.do https://webapp1.dlib.indiana.edu/newton/project/about.do Its actually pretty common to venture outside the box in every regard, if you have the ability to venture outside the box.
  - ASalazarMX 5y ago
    But horoscopes, my god. They're not outside the box, they're outside reality. It's like a physicist believing in perpetual motion.
    - tedunangst 5y ago
      But they're a biologist? Cosmic forces are outside their field, unlike a physicist who believes in perpetual motion.
      - ASalazarMX 5y ago
        Biologists have to know statistics. Horoscopes are evidently impossible to anyone who knows basic statistics, if the generic fortunes weren't evident enough.
        tedunangst 5y ago
        Are they? If the newspaper says Pisces is going to have a good day and Libra is going to have a bad day, I feel I'd have to ask way more people than I'm likely to meet to determine whether it's true or not. I don't know why you'd say it's evidently impossible.

koheripbal 5y ago

His argument is fallacious. He's saying that since there all other variants we're susceptible to the vaccine, it's unlikely that this one is. ...and goes on to list the high number of different markers the vaccines target. Unfortunately, vaccines largely target the spike proteins, and sequencing of omicron is demonstrating that every single protein marker on the spike is changed. Vaccines will likely have a very small effect on this variant. There are also two other mutations of concern that have never been seen together that each increase binding to ACE2 for cell entry. This all needs to be formally confirmed, but this is probably BAD.

fartattack 5y ago
Your argument is fallacious. You clearly lack even an elementary education in immunology. Exposure to the antigen teaches your immune memory cells what the antigen looks like. Quit your job, stay home, live in fear. The rest of society doesn't need cowards like you. The pandemic is over, except for paranoid people. There will be endless variants. It's an RNA virus. No amount of vaccination will be perfect, but life will go on. Get vaccinated and go expose yourself to the existing endemic variants; it's the best defense there is. Live your life. If you think you can wait until there are no more variants, you'll be locked inside wearing a mask forever. Some of us have lives to lead.
Kye 5y ago
Chise is a she/her-shaped creature as far as I know.
op00to 5y ago
No. If every single “protein marker” on the spike protein was changed, there wouldn’t be a heck of a lot of chance for the virus to attach to a cell. There still needs to be basic compatibility with the cell and the spike to get inside.
- chii 5y ago
  > there wouldn’t be a heck of a lot of chance for the virus to attach to a cell. but there isn't just a single shape that could be used to attach to a cell. Another shape could be compatible, but is not targeted by the vaccine of today. I'm guessing that this makes the virus a different virus - but isn't that what mutations are? they are slowly causing the virus to change and at some point, it becomes a different virus.