5 ms·
The 5ht2a agonism is what’s similar. LSD is made unique by its strong dopamine subreceptor agonism. So no, shrooms and LSD are most different in the dopaminergi
by __blockcipher__ 5y ago
The 5ht2a agonism is what’s similar. LSD is made unique by its strong dopamine subreceptor agonism. So no, shrooms and LSD are most different in the dopaminergic effects of lsd and the half lives (lsd 2-4x longer). LSD is more of a psychedelic amphetamine whereas psilocybin is a classic tryptamine
- eurasiantiger 5y agoActually no. LSD is a direct-acting sympathomimetic drug; it directly binds to serotonin and dopamine receptors to activate them. Amphetamines, like all phenethylamines typically, are not direct-acting sympathomimetic, but indirect-acting; amphetamines elicit their effects through blockage and reversal of NET and DAT, the norepinephrine and dopamine transporter proteins. They are, however, TAAR1 agonists, which is currently thought to be partially responsible for regulating downstream effects on dopamine neurotransmission. LSD is best described as a lysergamide.
- Jerrrry 5y agoHello. Long lover of lyseragmides and novel phenethylamines, and stoner. Why does smoking have an immediate intensification effect when combined with lysergamides? Is it because of the combination of partial antagonism and down regulation blocking of certain receptors?
- eurasiantiger 5y agoImmediate effects are most likely due to smoke containing large amounts of various monoamine oxidase inhibitors.