While I'm ranting: if your interest lies in becoming more productive as a programmer, these are not the droids you're looking for. Some people have put forward

While I'm ranting: if your interest lies in becoming more productive as a programmer, these are not the droids you're looking for. Some people have put forward anecdotal evidence to the contrary, but I personally can't see it being either likely or worthwhile (taken in isolation). Good sleep, meditation, regular exercise, a good diet, vitamin or fish oil supplements, possibly responsible use of some stimulants (caffeine, dexamphetamine, methylphenidate, etc - I do NOT advise using methamphetamine), quiet work spaces, trying different tactics (e.g. pomodoro technique) for minimising disruption and improving your concentration, fostering dedication to your craft - all of these are much more likely and FAR less risky candidates for making you a better programmer. And as others here have alluded to, psychedelics yield diminishing returns. One or two trips could change your life and transform your outlook, hopefully for the better; using a psychedelic experience to collect and align your energies up to a few times a year could be a positive influence. Taking them more often than that qualifies as abuse, and will not help you.