4 ms·

40% of cases of schizophrenia are from the immune system attacking synapses in the brain.

by monotone666 8y ago

loceng 8y ago
Do you have any links to research or papers on this? Thanks.
- monotone666 8y ago
  https://www.nature.com/articles/s41380-018-0235-x https://www.nature.com/articles/s41380-018-0235-x
  - mpol 8y ago
    Thank you. Any tips for lowering inflammation? I only know of these; lower intake of alcohol, sleep well, kurkuma, aspirin. Just as a datapoint, I suffer from psychosis and experience a good response to aspirin.
    - tsomctl 8y ago
      Eat an anti inflammatory diet. See Anti-Inflammatory Recipes: The Complete Guide by David Colombo. Also, take a glycine supplement or drink lots of bone broth to boost your glutathione levels (your body's natural antioxidant). Muscle meat has glycine in it too, but most of it goes towards counteracting the methionine that's also in muscle meat. > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855430/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855430/
    - loceng 8y ago
      CBD oil is a very powerful anti-inflammatory; CBD can be more effective for people if mixed with some THC, CBD counteracts the psychoactive properties of THC, however I believe THC is contraindicated for the diagnosis of schizophrenia?
      - mpol 8y ago
        Thank you. CBD oil is something worth to try out then. THC delivers the high in the weed. I know people who use pot, but I stay far away from it.
        SuoDuanDao 8y ago
        probably a good policy - THC exacerbates the inflammatory symptoms that CBD alleviates. There's a theory that older people who used to self-medicate with CBD-rich cannabis in their youth are now doing more harm than good because of increased breeding for higher THC content.
  - stenl 8y ago
    Neuroscientist here. The study shows no such thing. Maybe you refer to this: ”for the first time, identifies brain tissue macrophages proximal to neurons in over 40% of individuals with schizophrenia who are in a high inflammatory state.” But first, the authors are confused. All brains (100%) contain macrophages in proximity to neurons. Specifically microglia (which are macrophages) and perivascular macrophages. Second, note that they studied cases already selected to be in a high inflammatory state. Third, they do not show the direction of causality. It’s easy to imagine how a life lived with schizophrenia could substantially increase your risk of inflammation.
    - tcj_phx 8y ago
      > Third, they do not show the direction of causality. It’s easy to imagine how a life lived with schizophrenia could substantially increase your risk of inflammation. Schizophrenia is a manifestation of "stress" (infections/drug use/injuries/emotions/malnourishment/etc) that's worsened by standard treatments. Some of the drugs used to treat "psychosis" seem to cause inflammation. Patients treated with anti-psychotics have been found to suffer more deterioration than those who are never treated with anti-psychotics. My friend was eating a lot of soybean oil and alcohol in the months before she was captured by the mental health industry. Soybean oil is a source of Omega-6 oil, which breaks down into inflammatory prostaglandins. Alcohol contributes to inflammation too. Instead of treating the causes of her presentation, the professionals treat her symptoms. At one point they tried to label her "schizophrenic". Sometimes medical diagnoses are helpful. The diagnosis of "schizophrenia" is a non-helpful medical curse. There are some good psychiatrists, but the profession desperately needs help.
dwaltrip 8y ago
I've never heard this before. I echo the other commenter's request for sources.
- Mononokay 8y ago
  https://www.nature.com/articles/s41380-018-0235-x https://www.nature.com/articles/s41380-018-0235-x
progr4mmatic 8y ago
interesting. Have you read up on the new research that shows that DNA from mitochondria leaks out during stress and is treated as a foreign invader?
wu-ikkyu 8y ago
No, there is no known cause of schizophrenia.

40% of cases of schizophrenia are from the immune system attacking synapses in the brain.

loceng 8y ago

Do you have any links to research or papers on this? Thanks.

monotone666 8y ago
https://www.nature.com/articles/s41380-018-0235-x https://www.nature.com/articles/s41380-018-0235-x
- mpol 8y ago
  Thank you. Any tips for lowering inflammation? I only know of these; lower intake of alcohol, sleep well, kurkuma, aspirin. Just as a datapoint, I suffer from psychosis and experience a good response to aspirin.
  - tsomctl 8y ago
    Eat an anti inflammatory diet. See Anti-Inflammatory Recipes: The Complete Guide by David Colombo. Also, take a glycine supplement or drink lots of bone broth to boost your glutathione levels (your body's natural antioxidant). Muscle meat has glycine in it too, but most of it goes towards counteracting the methionine that's also in muscle meat. > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855430/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855430/
  - loceng 8y ago
    CBD oil is a very powerful anti-inflammatory; CBD can be more effective for people if mixed with some THC, CBD counteracts the psychoactive properties of THC, however I believe THC is contraindicated for the diagnosis of schizophrenia?
    - mpol 8y ago
      Thank you. CBD oil is something worth to try out then. THC delivers the high in the weed. I know people who use pot, but I stay far away from it.
      - SuoDuanDao 8y ago
        probably a good policy - THC exacerbates the inflammatory symptoms that CBD alleviates. There's a theory that older people who used to self-medicate with CBD-rich cannabis in their youth are now doing more harm than good because of increased breeding for higher THC content.
- stenl 8y ago
  Neuroscientist here. The study shows no such thing. Maybe you refer to this: ”for the first time, identifies brain tissue macrophages proximal to neurons in over 40% of individuals with schizophrenia who are in a high inflammatory state.” But first, the authors are confused. All brains (100%) contain macrophages in proximity to neurons. Specifically microglia (which are macrophages) and perivascular macrophages. Second, note that they studied cases already selected to be in a high inflammatory state. Third, they do not show the direction of causality. It’s easy to imagine how a life lived with schizophrenia could substantially increase your risk of inflammation.
  - tcj_phx 8y ago
    > Third, they do not show the direction of causality. It’s easy to imagine how a life lived with schizophrenia could substantially increase your risk of inflammation. Schizophrenia is a manifestation of "stress" (infections/drug use/injuries/emotions/malnourishment/etc) that's worsened by standard treatments. Some of the drugs used to treat "psychosis" seem to cause inflammation. Patients treated with anti-psychotics have been found to suffer more deterioration than those who are never treated with anti-psychotics. My friend was eating a lot of soybean oil and alcohol in the months before she was captured by the mental health industry. Soybean oil is a source of Omega-6 oil, which breaks down into inflammatory prostaglandins. Alcohol contributes to inflammation too. Instead of treating the causes of her presentation, the professionals treat her symptoms. At one point they tried to label her "schizophrenic". Sometimes medical diagnoses are helpful. The diagnosis of "schizophrenia" is a non-helpful medical curse. There are some good psychiatrists, but the profession desperately needs help.

dwaltrip 8y ago

I've never heard this before. I echo the other commenter's request for sources.

Mononokay 8y ago
https://www.nature.com/articles/s41380-018-0235-x https://www.nature.com/articles/s41380-018-0235-x

progr4mmatic 8y ago

interesting. Have you read up on the new research that shows that DNA from mitochondria leaks out during stress and is treated as a foreign invader?

wu-ikkyu 8y ago

No, there is no known cause of schizophrenia.