6 ms·

A quick search on Google Scholar reveals more studies confirming this: [1] [2] [3]. It might be worth trying out, since it seems to be pretty hard to overdose o

A quick search on Google Scholar reveals more studies confirming this: [1] [2] [3]. It might be worth trying out, since it seems to be pretty hard to overdose on magnesium unless you have kidney failure. [4] [1] http://ijp.sagepub.com/content/19/1/57.short http://ijp.sagepub.com/content/19/1/57.short [2] https://www.researchgate.net/profile/Betina_Elfving/publication/272513367_Dietary_magnesium_deficiency_alters_gut_microbiota_and_leads_to_depressive-like_behaviour/links/560a742208ae1396914bd253.pdf https://www.researchgate.net/profile/Betina_Elfving/publicat... [3] https://www.researchgate.net/profile/Claudia_Schmuckermair/publication/262149492_Dietary_magnesium_restriction_reduces_amygdala-hypothalamic_GluN1_receptor_complex_levels_in_mice/links/5405d27e0cf2bba34c1db295.pdf https://www.researchgate.net/profile/Claudia_Schmuckermair/p... [4] https://en.wikipedia.org/wiki/Hypermagnesemia https://en.wikipedia.org/wiki/Hypermagnesemia

sbierwagen 11y ago
1 is behind a paywall, so you can't see how many patients were in the study or what the effect size was. 2 and 3 were in mice. Mice are useful model organisms for many things, but it is very important to remember they are not humans. For one, they have wildly different inflammation responses, (http://blogs.sciencemag.org/pipeline/archives/2013/02/13/mouse_models_of_inflammation_are_basically_worthless_now_we_know http://blogs.sciencemag.org/pipeline/archives/2013/02/13/mou... ) and inflammation is yet another thing that seems to influence mental illness.
- photoJ 11y ago
  From Journal of Immunology with impact factor 4.92 Note the following quotes are take from an article that's "aim is to sound a word of caution" about the use of mice as a substitute for human studies. Even they note how well mice have served and will continue to serve as a model for human biology. "Mice are the mainstay of in vivo immunological experimentation and in many respects they mirror human biology remarkably well." "In this review our aim is not to suggest that the mouse is an invalid model system for human biology. Clearly, with so many paradigms that translate well between the species, and with the relative ease with which mice can now be genetically manipulated, mouse models will continue to provide important information for many years to come. " http://www.jimmunol.org/content/172/5/2731.full http://www.jimmunol.org/content/172/5/2731.full
  - sbierwagen 11y ago
    Yes, and that is indeed the journal of immunology, which is speaking of mice in a primarily immunological context. One might easily guess that mice are less useful model organisms in neurology.

sbierwagen 11y ago

1 is behind a paywall, so you can't see how many patients were in the study or what the effect size was. 2 and 3 were in mice. Mice are useful model organisms for many things, but it is very important to remember they are not humans. For one, they have wildly different inflammation responses, (http://blogs.sciencemag.org/pipeline/archives/2013/02/13/mouse_models_of_inflammation_are_basically_worthless_now_we_know http://blogs.sciencemag.org/pipeline/archives/2013/02/13/mou... ) and inflammation is yet another thing that seems to influence mental illness.

photoJ 11y ago
From Journal of Immunology with impact factor 4.92 Note the following quotes are take from an article that's "aim is to sound a word of caution" about the use of mice as a substitute for human studies. Even they note how well mice have served and will continue to serve as a model for human biology. "Mice are the mainstay of in vivo immunological experimentation and in many respects they mirror human biology remarkably well." "In this review our aim is not to suggest that the mouse is an invalid model system for human biology. Clearly, with so many paradigms that translate well between the species, and with the relative ease with which mice can now be genetically manipulated, mouse models will continue to provide important information for many years to come. " http://www.jimmunol.org/content/172/5/2731.full http://www.jimmunol.org/content/172/5/2731.full
- sbierwagen 11y ago
  Yes, and that is indeed the journal of immunology, which is speaking of mice in a primarily immunological context. One might easily guess that mice are less useful model organisms in neurology.