11 ms·

Doesn't "equivalent to" in this case mean "the mice equivalent to the maximum accetptable in humans"?

by malvim 12y ago

sentenza 12y ago
It does. I'm no experimentalist, but my naive assumption (gut feeling, heh) would be that the way to do this is to scale by body mass.
- jimcsharp 12y ago
  That's a really charming synonym for 'scientist'
  - pdpi 12y ago
    Not quite. Scientists also come in the Theoretician variety.
  - raverbashing 12y ago
    The theorists disagree with you, and I'm sure they have a long paper with lots of equations explaining why. (it's a joke)
  - Steuard 12y ago
    What, "experimentalist"? That's not a synonym for "scientist", it's a subset. At least in physics, the main categories are "experimentalist" and "theorist". You'll sometimes find intermediate categories like "phenomenologist" (people who apply basic theory to make detailed predictions for experimental measurements) or "computational(-ist?)" (people who measure experimental-style results from simulations of basic theory).
    - kaybe 12y ago
      I think we should add a third category, 'modeller', as in someone who runs experiments in silica. It's not really an experiment, and it's not really just theory.
      - Steuard 12y ago
        Assuming I understand you, that's what I was getting at with "computational" scientists as a separate or intermediate category.
- tP5n 12y ago
  Almost, you scale by their metabolic weight. It's about 7 times higher for mice than for humans. I'm not a scientist (heh) so the best explanation a quick google search gave was an article on CLA from the jn - journal of nutrition: "The relationship between basal metabolic rate or energy expenditure and body weight in different size mammals is described by the function Y = aX0.75, where Y is basal metabolic rate (kJ/d), X is body weight (kg) and a is basal metabolic rate per kg0.75 per day, which is ∼300 kJ/ (kg0.75 · d). Thus, the basal metabolic rate in different size species is proportional to the body weight raised to the 0.75 power, the so called metabolic weight." http://jn.nutrition.org/content/131/7/2067.full http://jn.nutrition.org/content/131/7/2067.full

Doesn't "equivalent to" in this case mean "the mice equivalent to the maximum accetptable in humans"?

by malvim 12y ago

Doesn't "equivalent to" in this case mean "the mice equivalent to the maximum accetptable in humans"?

It does. I'm no experimentalist, but my naive assumption (gut feeling, heh) would be that the way to do this is to scale by body mass.

jimcsharp 12y ago
That's a really charming synonym for 'scientist'
- pdpi 12y ago
  Not quite. Scientists also come in the Theoretician variety.
- raverbashing 12y ago
  The theorists disagree with you, and I'm sure they have a long paper with lots of equations explaining why. (it's a joke)
- Steuard 12y ago
  What, "experimentalist"? That's not a synonym for "scientist", it's a subset. At least in physics, the main categories are "experimentalist" and "theorist". You'll sometimes find intermediate categories like "phenomenologist" (people who apply basic theory to make detailed predictions for experimental measurements) or "computational(-ist?)" (people who measure experimental-style results from simulations of basic theory).
  - kaybe 12y ago
    I think we should add a third category, 'modeller', as in someone who runs experiments in silica. It's not really an experiment, and it's not really just theory.
    - Steuard 12y ago
      Assuming I understand you, that's what I was getting at with "computational" scientists as a separate or intermediate category.
tP5n 12y ago
Almost, you scale by their metabolic weight. It's about 7 times higher for mice than for humans. I'm not a scientist (heh) so the best explanation a quick google search gave was an article on CLA from the jn - journal of nutrition: "The relationship between basal metabolic rate or energy expenditure and body weight in different size mammals is described by the function Y = aX0.75, where Y is basal metabolic rate (kJ/d), X is body weight (kg) and a is basal metabolic rate per kg0.75 per day, which is ∼300 kJ/ (kg0.75 · d). Thus, the basal metabolic rate in different size species is proportional to the body weight raised to the 0.75 power, the so called metabolic weight." http://jn.nutrition.org/content/131/7/2067.full http://jn.nutrition.org/content/131/7/2067.full