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A problem with these wall charts and the KEGG diagrams is that not only do you not know which enzymes or pathways are active in which tissues within a single mu
by taltman1 12y ago
A problem with these wall charts and the KEGG diagrams is that not only do you not know which enzymes or pathways are active in which tissues within a single multi-cellular organism, you don't know which organisms they come from. These pathway charts are actually mosaic pathways, trying to show a summary of metabolism across all domains of life. This can be misleading, in that no one organism contains all parts as displayed.
- dnautics 12y agoKEGG filters for organism, although it's automated and not 100% correct. There's also a lot that's not on either map, like specialized secondary metabolite synthesis pathways (although kegg has select secondary pathways).
- taltman1 12y agoKEGG filters at the MAP or MODULE level, but it merely highlights the enzymes of the mosaic MAP/MODULE that it inferred is present in the organism, rather than display the subset of the network that is actually present. I agree with you regarding their mutual incompleteness. There's plenty more literature to curate! See my systematic omparison of KEGG and MetaCyc for more details: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665663/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665663/