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I see no reason why a mitochondrial DNA test would be helpful - your point is that the mitochondria are maternally inherited? 1. Mitochondrial DNA is less apt
by ronaldx 12y ago
I see no reason why a mitochondrial DNA test would be helpful - your point is that the mitochondria are maternally inherited?
1. Mitochondrial DNA is less apt than regular DNA to accurately identify motherhood since it has a low mutation rate.
2. The mitochondria would still come from the chimeric cells which still are a generation away from the mother's cells.
3. If you have have considered the possibility of chimerism, there are much simpler tests - e.g. the tests that they did do.
- josu 12y agoAFAIK -and please do correct me if I am wrong - twins have the same mitochondrial DNA, therefore even if she is a chimera all her cells should share the same mitochondrial DNA. And isn't testing for mitochondrial DNA fairly simple/cheap?
- ronaldx 12y agoMitochondrial DNA between twins is expected to be almost identical, but you and I also have extremely similar mitochondria: since it doesn't recombine and rarely mutates. So, you have to get to a much deeper level to identify the differences. Even if it's now possible/cheap, that's a recent development. mtDNA is good for finding your (maternal) ancestral group, less so for your immediate relatives.