7 ms·

In theory, nerve connection is quite easy. Put two nerves of the same type right up next to each other and they will fuse and form a continuous signal transduct

by arm55 12y ago

In theory, nerve connection is quite easy. Put two nerves of the same type right up next to each other and they will fuse and form a continuous signal transduction pathway. However, the success rate for this is somewhere on the order of 80%. Assuming there are ~100 connections to be made, 0.80^100 isn't very enticing. Perhaps using the compounds he talks about can increase the success rate, but this is still on fairly shaky grounds.

dmitrygr 12y ago
http://en.wikipedia.org/wiki/Neuroplasticity http://en.wikipedia.org/wiki/Neuroplasticity
mbenjaminsmith 12y ago
Actually, if I'm reading wikipedia correctly, there are only 62 connections that need to be made. While that doesn't help with the error rate it seems feasible to make that many connections individually in a short period of time, if that is in fact what they're doing.
- shutupalready 12y ago
  > if I'm reading wikipedia correctly, there are only 62 connections For others, here's the Wikipedia link: http://en.wikipedia.org/wiki/Spinal_nerves http://en.wikipedia.org/wiki/Spinal_nerves I'm surprised that it's so few (31 pairs of spinal nerves). I would have imagined that there would be thousands and thousands of nerves. Since we certainly have more than 62 sensory inputs and motor outputs in the trunk of our body, I assume that those 62 nerves hide quite a lot complexity.
- icegreentea 12y ago
  The spinal nerves (by and large) originate in the spinal cord at their level of origin. That is to say that if you severed the spinal cord at some point, you could not 'split out' the connections corresponding to the lower spinal nerves from the overall bundle. Amongst other things, the spinal cord also contains neurons that form closed circuits without reaching the brain (these make up your reflexes). So, if you transplanted the head and spinal cord, then use, you could somehow make '62 connections'. If you transplanted 'the head' you would have to join the entire spinal cords. Finally, each nerve is really 'a cable bundle', so the process of joining them is kinda tricky, and beyond the scope of my knowledge. Needless to say, the authors of the paper think that it can work. Their references likely can point you in the right direction.
- deleted 12y ago
  [deleted]
khyryk 12y ago
0.8 ^ 100 simply means that it's extremely unlikely that there would be 100 out of 100 successful connections given that the probability of the success of each connection is 0.8. The expected success rate would still be around 80 out of 100.
- arm55 12y ago
  Yes, but even if a few spinal nerves don't get connected, you'll have severe motility problems.

by arm55 12y ago

dmitrygr 12y ago

http://en.wikipedia.org/wiki/Neuroplasticity http://en.wikipedia.org/wiki/Neuroplasticity

mbenjaminsmith 12y ago

Actually, if I'm reading wikipedia correctly, there are only 62 connections that need to be made. While that doesn't help with the error rate it seems feasible to make that many connections individually in a short period of time, if that is in fact what they're doing.

shutupalready 12y ago
> if I'm reading wikipedia correctly, there are only 62 connections For others, here's the Wikipedia link: http://en.wikipedia.org/wiki/Spinal_nerves http://en.wikipedia.org/wiki/Spinal_nerves I'm surprised that it's so few (31 pairs of spinal nerves). I would have imagined that there would be thousands and thousands of nerves. Since we certainly have more than 62 sensory inputs and motor outputs in the trunk of our body, I assume that those 62 nerves hide quite a lot complexity.
icegreentea 12y ago
The spinal nerves (by and large) originate in the spinal cord at their level of origin. That is to say that if you severed the spinal cord at some point, you could not 'split out' the connections corresponding to the lower spinal nerves from the overall bundle. Amongst other things, the spinal cord also contains neurons that form closed circuits without reaching the brain (these make up your reflexes). So, if you transplanted the head and spinal cord, then use, you could somehow make '62 connections'. If you transplanted 'the head' you would have to join the entire spinal cords. Finally, each nerve is really 'a cable bundle', so the process of joining them is kinda tricky, and beyond the scope of my knowledge. Needless to say, the authors of the paper think that it can work. Their references likely can point you in the right direction.
deleted 12y ago
[deleted]

khyryk 12y ago

0.8 ^ 100 simply means that it's extremely unlikely that there would be 100 out of 100 successful connections given that the probability of the success of each connection is 0.8. The expected success rate would still be around 80 out of 100.

arm55 12y ago
Yes, but even if a few spinal nerves don't get connected, you'll have severe motility problems.