We do it the other way round to your suggestion. SQL Server + NHibernate does handle the CRUD stuff, custom fields and DDD-based domain logic very well. NoSQL

We do it the other way round to your suggestion. SQL Server + NHibernate does handle the CRUD stuff, custom fields and DDD-based domain logic very well. NoSQL (CouchDB in our case) doesn't handle transactions, locking and business rules effectively. However it excels at providing extremely fast views on schemaless data such as our core domain model plus custom fields.