I agree for the most part, however when I'm at the design phase I'm generally working from required brand palettes or using swatches I've defined so I know the

I agree for the most part, however when I'm at the design phase I'm generally working from required brand palettes or using swatches I've defined so I know the colors are good. Maybe I'm Doing It Wrong™, but I design all the time with F.lux in this manner and don't have any problems.