Here you go: http://money.cnn.com/calculator/pf/cost-of-living/ http://money.cnn.com/calculator/pf/cost-of-living/ Enter St. Louis, MO and San Francisco, CA.

Here you go: http://money.cnn.com/calculator/pf/cost-of-living/ http://money.cnn.com/calculator/pf/cost-of-living/ Enter St. Louis, MO and San Francisco, CA. Housing is 276% more expensive. Columbia? 252%. Kansas City? 215%. You get the idea. Also, just for fun, try some other "large towns": Dallas, TX: 276% Columbus, OH: 268% Austin, TX: 245% Jacksonville, FL: 242% Phoenix, AZ: 225% Atlanta, GA: 217%