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Menthol is wild. Lightly edited from Wikipedia: "Menthol's [agonism of] the cold-sensitive Transient Receptor Potential cation channel subfamily M (melastatin
by AnthonBerg 23d ago
Menthol is wild.
Lightly edited from Wikipedia:
"Menthol's [agonism of] the cold-sensitive Transient Receptor Potential cation channel subfamily M (melastatin) member 8 or TRPM8 receptors is responsible for the well-known cooling sensation it provokes.
Menthol's analgesic properties are mediated through a selective activation of κ-opioid receptors. Menthol blocks calcium channels and voltage-sensitive sodium channels, reducing neural activity that may stimulate muscles.
Some studies show that menthol acts as a GABAᴀ receptor positive allosteric modulator and increases GABAergic transmission in PAG neurons."
…and! Check this out:
"Menthol has anesthetic properties similar to though less potent than propofol, interacting with the same sites on the GABAᴀ receptor."
Propofol. PROPOFOL. The -ol in propofol is the -ol in menthol, haha.
"Menthol may also enhance the activity of glycine receptors and negatively modulate 5-HT3 receptors and nAChRs."
Aaaaand:
"Menthol also lowers blood pressure and antagonizes vasoconstriction through TRPM8 activation."
- arthurptj 23d agomany things are wild, just menthol has been studied for the past 50yrs
- AnthonBerg 23d agoWell said!! My point was exactly the hope to indicate how much knowledge there exists. That's the truly wild thing. Or yeah, how unread most of it lays.
- Noaidi 23d agoPeppermint is even more wild becasue while Menthol is a TRPM8 agonist (cold sensation), ECGC, also very high in peppermint, is a TRPV1 agonist (warm sensation), which has the opposite effect of TRPM8. The EGCG is probably what is reducing the blood pressure. Transient receptor potential vanilloid type 1 is vital for (−)-epigallocatechin-3-gallate mediated activation of endothelial nitric oxide synthase https://onlinelibrary.wiley.com/doi/10.1002/mnfr.201400699 https://onlinelibrary.wiley.com/doi/10.1002/mnfr.201400699 Cardioprotective and Anti-Hypertensive Effects of Epigallocatechin Gallate: Novel Insights Into Biological Evidence https://onlinelibrary.wiley.com/doi/full/10.1111/jch.70036 https://onlinelibrary.wiley.com/doi/full/10.1111/jch.70036 Anything with EGCG in it causes me extreme bladder pain, even peppermint tea. While taking tons of Ricola cough drops (high in mentol) once when I had covid I found my bladder pain vanished. I then learned how the TRPV1 receptor is involved in my bladder pain. https://www.nature.com/articles/s41598-018-24056-0 https://www.nature.com/articles/s41598-018-24056-0 I
- AnthonBerg 23d agoExploding-head emoji reaction here, both generally and specifically. Thank you.