13 ms·

Pharma and Healthcare was the implication I believe. The US approach to these things has a bad reputation internationally though I am informed that it’s an amaz

by rusk 1mo ago

Pharma and Healthcare was the implication I believe. The US approach to these things has a bad reputation internationally though I am informed that it’s an amazing system if you’re rich.

mft_ 1mo ago
Let’s not conflate US pharma with their healthcare more generally. The US is dominant in pharmaceutical and biotech, and FDA is generally excellent as a regulator, despite (IMO) sometimes being too conservative and resistant to any ideas not gestated within the agency. There are weird quirks (like the wide and wacky dosages of melatonin available over the counter, in this example) but most countries have such quirks.
- Angostura 1mo ago
  As I understand it, the FDA doesn't regulate melatonin as it's not sold as a medication, but as a supplement.
  - mft_ 1mo ago
    FDA does regulate supplements, but using a different legal framework which is far, far more hands-off than for pharmaceuticals.
- Spooky23 1mo ago
  Irrelevant due to a scoping problem. If you’re peddling a dietary supplement there is virtually no regulation at all. As long as you don’t say anything in the marketing material, you’re good. The only science in supplements is the marketing.
mlrtime 1mo ago
Are you implying that everyone in the US is taking unknown quantities of OTC medications? Unless you have some data to backup this claim, it is tinfoil hat speaking.
- mettamage 1mo ago
  US melatonin measured dosage can be 4x as much as what is reported [1, 2]. Have you never looked into stuff like this? It's all over social media and the claims are relatively easy to verify. I'm asking because I need to know if I'm in a bubble or not. [1] Cohen PA, Avula B, Wang YH, Katragunta K, Khan I. Quantity of Melatonin and CBD in Melatonin Gummies Sold in the US. JAMA. 2023;329(16):1401–1402. doi:10.1001/jama.2023.2296 https://pmc.ncbi.nlm.nih.gov/articles/PMC10130950/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10130950/ [2] Erland LAE, Saxena PK. Melatonin Natural Health Products and Supplements: Presence of Serotonin and Significant Variability of Melatonin Content. J Clin Sleep Med. 2017;13(2):275–281. doi:10.5664/jcsm.6462 https://link.springer.com/article/10.5664/jcsm.6462 https://link.springer.com/article/10.5664/jcsm.6462
- amanaplanacanal 1mo ago
  In the US its regulated as a supplement, not an over the counter medication.

by rusk 1mo ago

Pharma and Healthcare was the implication I believe. The US approach to these things has a bad reputation internationally though I am informed that it’s an amazing system if you’re rich.

mft_ 1mo ago

Let’s not conflate US pharma with their healthcare more generally. The US is dominant in pharmaceutical and biotech, and FDA is generally excellent as a regulator, despite (IMO) sometimes being too conservative and resistant to any ideas not gestated within the agency. There are weird quirks (like the wide and wacky dosages of melatonin available over the counter, in this example) but most countries have such quirks.

Angostura 1mo ago
As I understand it, the FDA doesn't regulate melatonin as it's not sold as a medication, but as a supplement.
- mft_ 1mo ago
  FDA does regulate supplements, but using a different legal framework which is far, far more hands-off than for pharmaceuticals.
Spooky23 1mo ago
Irrelevant due to a scoping problem. If you’re peddling a dietary supplement there is virtually no regulation at all. As long as you don’t say anything in the marketing material, you’re good. The only science in supplements is the marketing.

mlrtime 1mo ago

Are you implying that everyone in the US is taking unknown quantities of OTC medications? Unless you have some data to backup this claim, it is tinfoil hat speaking.

mettamage 1mo ago
US melatonin measured dosage can be 4x as much as what is reported [1, 2]. Have you never looked into stuff like this? It's all over social media and the claims are relatively easy to verify. I'm asking because I need to know if I'm in a bubble or not. [1] Cohen PA, Avula B, Wang YH, Katragunta K, Khan I. Quantity of Melatonin and CBD in Melatonin Gummies Sold in the US. JAMA. 2023;329(16):1401–1402. doi:10.1001/jama.2023.2296 https://pmc.ncbi.nlm.nih.gov/articles/PMC10130950/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10130950/ [2] Erland LAE, Saxena PK. Melatonin Natural Health Products and Supplements: Presence of Serotonin and Significant Variability of Melatonin Content. J Clin Sleep Med. 2017;13(2):275–281. doi:10.5664/jcsm.6462 https://link.springer.com/article/10.5664/jcsm.6462 https://link.springer.com/article/10.5664/jcsm.6462
amanaplanacanal 1mo ago
In the US its regulated as a supplement, not an over the counter medication.