I think it's difficult to objectively quantify "effectively solved". A good source with loads of information about many diseases and their clinical status is Op

I think it's difficult to objectively quantify "effectively solved". A good source with loads of information about many diseases and their clinical status is OpenTargets, e.g. https://platform.opentargets.org/disease/EFO_0003860 https://platform.opentargets.org/disease/EFO_0003860