6 ms·
Alcohol is always poisonous (but mixed with methanol quite a bit more poisonous ) :-)
by frankzander 5mo ago
Alcohol is always poisonous (but mixed with methanol quite a bit more poisonous ) :-)
- dnnddidiej 5mo agoAnd if you have one of those poisons the antedote is the other one. Edit: only one way round! This is not medical advice. I am not a doctor. I am not your doctor or drinking doula.
- froh 5mo agoyou suggest additional drinking methanol when you're "normally" drunk?? that's dangerously counterfactual.
- dnnddidiej 5mo agovice versa > Ethanol is the most commonly used antidote to block the metabolising of methanol. Ethanol works by competing with the metabolic breakdown of methanol, thereby preventing the accumulation of toxic byproducts. MSF: https://methanolpoisoning.msf.org/en/for-health-professionals/ https://methanolpoisoning.msf.org/en/for-health-professional... I can see the ambiguity of my comment. I was trying to phrase as a riddle but can be interpreted both ways.
- adzm 5mo agoNo, ethanol is an antidote to methanol
- hilbert42 5mo agoWhere's the authority on that? Ethanol can be used as a temporary measure in methanol poisoning as it temporarily outcompetes methanol in the metabolic process. So it's only useful until proper medical help arrives when better alternatives such as fomepizole are administered. Even then there is no guarantee of success. Methanol is still metabolized to dangerous formaldehyde and formic acid by the liver's alcohol dehydrogenase. The logic of giving ethanol or fomepizole is to slow down the rate of production methanol's dangerous metabolic byproducts so less damage is done, nevertheless those dangerous metabolites are still produced. Ethanol's first-pass metabolite is acetaldehyde and it is still toxic but not to the same degree as those of methanol. It is incorrect to say ethanol is an antidote for methanol poisoning. Using ethanol is a last-ditch stand to try and take some minor control of an otherwise out of control situation. There's nothing subtle about it—it's a blunderbuss approach that often doesn't work well because replacing one poison with a less toxic one is a pretty hit-and-miss process. Antidotes counteract poisons, that's not what happens when you give ethanol in methanol poisonings.
- dnnddidiej 5mo agoIt is technically an antidote though. Based on the definition of antidote.
- btreecat 5mo agoWhere are the sources on your claims that ethenol is only a temporary or last ditch treatment?
- hilbert42 5mo agoSuggest you read the link in my reply to pessimizer.
- btreecat 5mo agoIf you don't want to provide a link and quote to the source, I'm going to treat it as it's unsourced. If you want to claim the link and source are in another castle, I'm not playing games. https://pmc.ncbi.nlm.nih.gov/articles/PMC1306022/ https://pmc.ncbi.nlm.nih.gov/articles/PMC1306022/ > A 10% ethanol solution administered intravenously is a safe and effective antidote for severe methanol poisoning. Ethanol therapy is recommended when plasma methanol concentrations are higher than 20 mg per dl, when ingested doses are greater than 30 ml and when there is evidence of acidosis or visual abnormalities in cases of suspected methanol poisoning.
- pcrh 5mo agoEthanol is a naturally occurring substance, humans and many animals have specifically evolved ways of processing it. In moderate doses it does no harm. It's almost impossible to avoid ingesting some alcohol during the course of a natural diet, and that includes if you avoid fermented food such as bread, let alone beverages deliberately brewed to be alcoholic.
- busymom0 5mo agoIsn't the problem of poisoning caused by Methanol and not Ethanol? Gemini says this: "Ethanol is the type of alcohol found in alcoholic beverages (beer, wine, spirits) meant for consumption. While ethanol is safe for moderate consumption, methanol is extremely toxic and can cause poisoning, blindness, or death, even in small amounts."
- pcrh 5mo agoI was replying to the statement that "alcohol is always poisonous". It isn't.