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It's interesting you mention this (anhedonia), since the guardian just published this article: https://www.theguardian.com/science/2026/apr/06/is-retatrutide-ex
by xarope 5mo ago
It's interesting you mention this (anhedonia), since the guardian just published this article: https://www.theguardian.com/science/2026/apr/06/is-retatrutide-experimental-weight-loss-drug-making-people-fall-out-of-love https://www.theguardian.com/science/2026/apr/06/is-retatruti...
How did you actually feel? Disinterested in stuff, ennui, or other?
- tbojanin 5mo agoYeah, basically disinterested. Somewhat burnt out from doing things I normally love doing such as going on walks, programming on weekends, gaming, and work. It wasn't a really big problem, I only noticed it when looking retroactively at my experience.
- bradlys 5mo agoHow much of that is just from your hormones being trashed due to a severe deficit? Large caloric deficits (1000+/day) in leaner people is known to tank T levels among other things. When I was on such large deficits, I had very weird mood/arousal swings. Nothing that problematic for someone with as much executive control as me but it was very weird to be held hostage to.