8 ms·
I work in this field. It’s more or less correct but kind of lacking in detail. Cancer is a property of all multicellular life. I think it’s best understood as t
by bglazer 6mo ago
I work in this field. It’s more or less correct but kind of lacking in detail. Cancer is a property of all multicellular life. I think it’s best understood as the behavior of a dynamical system that loses the feedback control that keeps cell growth under control.
Check out this paper from the Lander lab: https://elifesciences.org/articles/61026 https://elifesciences.org/articles/61026
It’s a bit jargon heavy but it’s a nice case study in how tumor growth is controlled through all the same mechanisms that normal tissue growth uses. Even cells with an outright cancerous gene mutation are basically still just doing normal growth and development.
- inglor_cz 6mo ago" Cancer is a property of all multicellular life." In practice, though, some species are way less prone to cancer than others. Orders of magnitude of a difference, even in mammals. Bats, notoriously. Or naked mole rats. On the other hand, mice get cancer fairly reliably. Which means that there are biologically realistic way how to keep the danger at bay, and they seem to involve the immune system.