This is possible in Twisted, using inline callbacks: try: data = doManyFancyThingsWith(yield asyncResult()) print 'Parsed data:', data except:

This is possible in Twisted, using inline callbacks: try: data = doManyFancyThingsWith(yield asyncResult()) print 'Parsed data:', data except: print 'Oh no, something went wrong!' I find that I use inline callbacks for the common case and work with deferreds directly only when it makes more sense to handle callbacks explicitly.