6 ms·

Your gut bacteria is the prevention and the cure.

wizzwizz4 7mo ago
That's a hypothesis. If we knew that for certain, it would be really big news; and we could investigate to learn why, and then we could isolate the causative factors and perhaps find other ways of deploying them… If you know something the rest of us don't, prove it: show us the evidence, show us the specific hypotheses, describe a repeatable experiment, show us the results if such an experiment has been performed. If you don't know something the rest of us don't, don't be so arrogant about your pet theories. Such arrogance costs lives.
- wordglyph 7mo ago
  You do realize they already are investigating, right? Even looking into MS and parkinson. ALZHEIMER’S DISEASE (AD) and AD DEMENTIA Umbrella review (systematic reviews of SRs): https://www.nature.com/articles/s44400-025-00048-6 https://www.nature.com/articles/s44400-025-00048-6 Systematic review + meta-analysis (basal microbiota; AD): https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/dad2.70057 https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002... https://pmc.ncbi.nlm.nih.gov/articles/PMC11672027/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11672027/ Replicated case-control + functional metagenomics (AD dementia): https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.70417 https://alz-journals.onlinelibrary.wiley.com/doi/full/10.100... Large-cohort metagenomics (stage-specific / early pathology signals): https://pubmed.ncbi.nlm.nih.gov/40164697 https://pubmed.ncbi.nlm.nih.gov/40164697 Mendelian randomization (AD): https://pubmed.ncbi.nlm.nih.gov/38788075/ https://pubmed.ncbi.nlm.nih.gov/38788075/ https://www.sciencedirect.com/science/article/pii/S2274580724007143 https://www.sciencedirect.com/science/article/pii/S227458072... https://pubmed.ncbi.nlm.nih.gov/40665707/ https://pubmed.ncbi.nlm.nih.gov/40665707/ https://journals.sagepub.com/doi/10.1177/25424823261422629 https://journals.sagepub.com/doi/10.1177/25424823261422629 https://www.medrxiv.org/content/10.1101/2025.08.20.25333769v1 https://www.medrxiv.org/content/10.1101/2025.08.20.25333769v... Narrative / mechanisms (useful synthesis, not primary causal proof): https://www.sciencedirect.com/science/article/abs/pii/S156816372400388X https://www.sciencedirect.com/science/article/abs/pii/S15681... MILD COGNITIVE IMPAIRMENT (MCI) / DEMENTIA (cognition-focused evidence) Systematic review (MCI or Alzheimer’s dementia; PRISMA, PROSPERO): https://www.mdpi.com/2035-8377/17/10/155 https://www.mdpi.com/2035-8377/17/10/155 https://pubmed.ncbi.nlm.nih.gov/41149776/ https://pubmed.ncbi.nlm.nih.gov/41149776/ Scoping review (MCI and AD gut microbiomes + interventions, through Feb 2023): https://pmc.ncbi.nlm.nih.gov/articles/PMC12825029/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12825029/ Systematic review of microbiota-targeted interventions for cognition/dementia risk: https://www.sciencedirect.com/science/article/pii/S0271531726000072 https://www.sciencedirect.com/science/article/pii/S027153172... RCT-focused systematic review/meta-analysis of probiotics for cognitive impairment risk/AD/MCI: https://pmc.ncbi.nlm.nih.gov/articles/PMC12645680/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12645680/ FMT in dementia/MCI context (review of effects across neuro cohorts): https://www.sciencedirect.com/science/article/pii/S2666354625001073 https://www.sciencedirect.com/science/article/pii/S266635462... MULTIPLE SCLEROSIS (MS) Microbiome signatures via global data integration / ML: https://pmc.ncbi.nlm.nih.gov/articles/PMC12383397/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12383397/ Systematic review/meta-analysis of probiotics in MS (preclinical + clinical): https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0319755 https://journals.plos.org/plosone/article?id=10.1371/journal... Systematic review + meta-analysis (antimicrobial exposure and MS risk; microbiome-disruption relevant): https://www.sciencedirect.com/science/article/abs/pii/S2211034825006741 https://www.sciencedirect.com/science/article/abs/pii/S22110... Mendelian randomization (gut microbiota causally linked to MS): https://pubmed.ncbi.nlm.nih.gov/39065244/ https://pubmed.ncbi.nlm.nih.gov/39065244/ https://www.mdpi.com/2076-2607/12/7/1476 https://www.mdpi.com/2076-2607/12/7/1476 Broad MS gut dysbiosis and therapeutic modulation review: https://pmc.ncbi.nlm.nih.gov/articles/PMC12668904/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12668904/ MS gut-brain-barrier and intestinal barrier review: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1652796/full https://www.frontiersin.org/journals/immunology/articles/10.... Example MS cohort biomarker/signature work: https://www.nature.com/articles/s41598-024-64369-x https://www.nature.com/articles/s41598-024-64369-x https://www.nature.com/articles/s41598-025-19998-1 https://www.nature.com/articles/s41598-025-19998-1 PARKINSON’S DISEASE (PD) Multi-cohort metagenomic meta-analysis (Nat Commun, 2025): https://www.nature.com/articles/s41467-025-56829-3 https://www.nature.com/articles/s41467-025-56829-3 https://pubmed.ncbi.nlm.nih.gov/40335465/ https://pubmed.ncbi.nlm.nih.gov/40335465/ Large metagenomics cohort (Nat Commun, 2022): https://www.nature.com/articles/s41467-022-34667-x https://www.nature.com/articles/s41467-022-34667-x Integrated multi-cohort gut metagenome (Movement Disorders, 2023): https://pubmed.ncbi.nlm.nih.gov/36691982/ https://pubmed.ncbi.nlm.nih.gov/36691982/ https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.29300 https://movementdisorders.onlinelibrary.wiley.com/doi/10.100... Metagenomic analysis (Movement Disorders, 2024): https://pubmed.ncbi.nlm.nih.gov/39192744/ https://pubmed.ncbi.nlm.nih.gov/39192744/ PD causal-inference and MR discussion (review-type synthesis): https://pmc.ncbi.nlm.nih.gov/articles/PMC12512240/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12512240/ MR study example (PD gut microbiota): https://journals.lww.com/md-journal/fulltext/2025/10310/causal_association_between_parkinson_disease%2C_gut.96.aspx https://journals.lww.com/md-journal/fulltext/2025/10310/caus...
  - wizzwizz4 7mo ago
    > You do realize they already are investigating, right? Yes. I also realise they have not reached the conclusion of this investigation. (Imagine this attitude towards a police investigation: "They're investigating Roger Rabbit, therefore he must have dunnit!")

That's a hypothesis. If we knew that for certain, it would be really big news; and we could investigate to learn why, and then we could isolate the causative factors and perhaps find other ways of deploying them… If you know something the rest of us don't, prove it: show us the evidence, show us the specific hypotheses, describe a repeatable experiment, show us the results if such an experiment has been performed. If you don't know something the rest of us don't, don't be so arrogant about your pet theories. Such arrogance costs lives.

wordglyph 7mo ago
You do realize they already are investigating, right? Even looking into MS and parkinson. ALZHEIMER’S DISEASE (AD) and AD DEMENTIA Umbrella review (systematic reviews of SRs): https://www.nature.com/articles/s44400-025-00048-6 https://www.nature.com/articles/s44400-025-00048-6 Systematic review + meta-analysis (basal microbiota; AD): https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/dad2.70057 https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002... https://pmc.ncbi.nlm.nih.gov/articles/PMC11672027/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11672027/ Replicated case-control + functional metagenomics (AD dementia): https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.70417 https://alz-journals.onlinelibrary.wiley.com/doi/full/10.100... Large-cohort metagenomics (stage-specific / early pathology signals): https://pubmed.ncbi.nlm.nih.gov/40164697 https://pubmed.ncbi.nlm.nih.gov/40164697 Mendelian randomization (AD): https://pubmed.ncbi.nlm.nih.gov/38788075/ https://pubmed.ncbi.nlm.nih.gov/38788075/ https://www.sciencedirect.com/science/article/pii/S2274580724007143 https://www.sciencedirect.com/science/article/pii/S227458072... https://pubmed.ncbi.nlm.nih.gov/40665707/ https://pubmed.ncbi.nlm.nih.gov/40665707/ https://journals.sagepub.com/doi/10.1177/25424823261422629 https://journals.sagepub.com/doi/10.1177/25424823261422629 https://www.medrxiv.org/content/10.1101/2025.08.20.25333769v1 https://www.medrxiv.org/content/10.1101/2025.08.20.25333769v... Narrative / mechanisms (useful synthesis, not primary causal proof): https://www.sciencedirect.com/science/article/abs/pii/S156816372400388X https://www.sciencedirect.com/science/article/abs/pii/S15681... MILD COGNITIVE IMPAIRMENT (MCI) / DEMENTIA (cognition-focused evidence) Systematic review (MCI or Alzheimer’s dementia; PRISMA, PROSPERO): https://www.mdpi.com/2035-8377/17/10/155 https://www.mdpi.com/2035-8377/17/10/155 https://pubmed.ncbi.nlm.nih.gov/41149776/ https://pubmed.ncbi.nlm.nih.gov/41149776/ Scoping review (MCI and AD gut microbiomes + interventions, through Feb 2023): https://pmc.ncbi.nlm.nih.gov/articles/PMC12825029/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12825029/ Systematic review of microbiota-targeted interventions for cognition/dementia risk: https://www.sciencedirect.com/science/article/pii/S0271531726000072 https://www.sciencedirect.com/science/article/pii/S027153172... RCT-focused systematic review/meta-analysis of probiotics for cognitive impairment risk/AD/MCI: https://pmc.ncbi.nlm.nih.gov/articles/PMC12645680/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12645680/ FMT in dementia/MCI context (review of effects across neuro cohorts): https://www.sciencedirect.com/science/article/pii/S2666354625001073 https://www.sciencedirect.com/science/article/pii/S266635462... MULTIPLE SCLEROSIS (MS) Microbiome signatures via global data integration / ML: https://pmc.ncbi.nlm.nih.gov/articles/PMC12383397/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12383397/ Systematic review/meta-analysis of probiotics in MS (preclinical + clinical): https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0319755 https://journals.plos.org/plosone/article?id=10.1371/journal... Systematic review + meta-analysis (antimicrobial exposure and MS risk; microbiome-disruption relevant): https://www.sciencedirect.com/science/article/abs/pii/S2211034825006741 https://www.sciencedirect.com/science/article/abs/pii/S22110... Mendelian randomization (gut microbiota causally linked to MS): https://pubmed.ncbi.nlm.nih.gov/39065244/ https://pubmed.ncbi.nlm.nih.gov/39065244/ https://www.mdpi.com/2076-2607/12/7/1476 https://www.mdpi.com/2076-2607/12/7/1476 Broad MS gut dysbiosis and therapeutic modulation review: https://pmc.ncbi.nlm.nih.gov/articles/PMC12668904/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12668904/ MS gut-brain-barrier and intestinal barrier review: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1652796/full https://www.frontiersin.org/journals/immunology/articles/10.... Example MS cohort biomarker/signature work: https://www.nature.com/articles/s41598-024-64369-x https://www.nature.com/articles/s41598-024-64369-x https://www.nature.com/articles/s41598-025-19998-1 https://www.nature.com/articles/s41598-025-19998-1 PARKINSON’S DISEASE (PD) Multi-cohort metagenomic meta-analysis (Nat Commun, 2025): https://www.nature.com/articles/s41467-025-56829-3 https://www.nature.com/articles/s41467-025-56829-3 https://pubmed.ncbi.nlm.nih.gov/40335465/ https://pubmed.ncbi.nlm.nih.gov/40335465/ Large metagenomics cohort (Nat Commun, 2022): https://www.nature.com/articles/s41467-022-34667-x https://www.nature.com/articles/s41467-022-34667-x Integrated multi-cohort gut metagenome (Movement Disorders, 2023): https://pubmed.ncbi.nlm.nih.gov/36691982/ https://pubmed.ncbi.nlm.nih.gov/36691982/ https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.29300 https://movementdisorders.onlinelibrary.wiley.com/doi/10.100... Metagenomic analysis (Movement Disorders, 2024): https://pubmed.ncbi.nlm.nih.gov/39192744/ https://pubmed.ncbi.nlm.nih.gov/39192744/ PD causal-inference and MR discussion (review-type synthesis): https://pmc.ncbi.nlm.nih.gov/articles/PMC12512240/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12512240/ MR study example (PD gut microbiota): https://journals.lww.com/md-journal/fulltext/2025/10310/causal_association_between_parkinson_disease%2C_gut.96.aspx https://journals.lww.com/md-journal/fulltext/2025/10310/caus...
- wizzwizz4 7mo ago
  > You do realize they already are investigating, right? Yes. I also realise they have not reached the conclusion of this investigation. (Imagine this attitude towards a police investigation: "They're investigating Roger Rabbit, therefore he must have dunnit!")