5 ms·
Given that it costs NN ~$5 to manufacture, and it's an effective drug that's an also-ran in the market, why still charge such a huge markup? NN should be sellin
by mjamil 1y ago
Given that it costs NN ~$5 to manufacture, and it's an effective drug that's an also-ran in the market, why still charge such a huge markup? NN should be selling it for $35-$50/month and buy the market share while feverishly working on a multi-GLP1 replacement.
- toomuchtodo 1y agoThey are milking the market up until the patent expires in Canada next year, at which point it’ll be imported into the US at scale. Novo’s already been beaten by Lilly with tirzepatide and orforglipron. (I pay $350/month cash rate for my partner’s monthly tirzepatide) https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-delivers-weight-loss-average-273 https://investor.lilly.com/news-releases/news-release-detail... How Ozempic's maker lost its shine after creating a wonder drug - https://news.ycombinator.com/item?id=44942077 https://news.ycombinator.com/item?id=44942077 - August 2025
- wpm 1y agoIs that $350/mo for the starter dose or higher?
- dkiebd 1y agoWait, you need a higher dose as time goes on?
- toomuchtodo 1y ago2.5mg starting dose, which is also their maintenance dose.
- phonon 1y agoMaximizing profits until retatrutide comes out and blows the whole market open.
- blacksmith_tb 1y agoStill sub-cutaneous, though? I would think whatever GLP-1 agonist that's oral-route will crush all of the competition instantly?
- phonon 1y agoWell, oral will be less effective (not a triple agonist like retatrutide) and might have greater side effects (the dose is larger since it goes through your digestive system) and you have to take it daily. But in any case, that will further box out semaglutide. Of course Novo has its own drug pipeline, but not clear if any of them are better than (or even equal to) retatrutide.
- haebom 1y agoWhen will Retatrutide release to the market?
- soegaard 1y agoThe US list prices are, well, a complicated matter. For non-US readers, it is important to note that 80% of the customers (who has insurance) don't pay the list price, but rather an much more reasonable over-the-counter price. Due to the system of insurance companies and PBMs in the US the list price is often high. When PBMs a are negotiating with the pharmaceutical companies, they have an incentive to keep a high list price. Let's say the PBMs and a pharmaceutical company negotiates for the price of a drug X. If the pharmaceutical company lowers the price of the drug X, and there are other comparable drugs from other companies on the market, then there is a risk that the PBM simply drops the drug X from their lists. Instead, they make a better deal (for them) on drug Y. For the company producing X, being omitted from the insurance companies lists, is bad business. As an outsider, it is difficult to understand that the US keeps the private insurance layer and the PBMS. Now - the insurance companies also don't pay list prices. They get a rebate. But they - and here my memory fails me - the get some money from ... the government based on the list price. Look at the congress hearings on the high medicine prices on YouTube.
- hulitu 1y agoAs the title says: "eligible US cash-paying customers". So cash milking citizens. /s