Is it even possible to solve the issue of there being no convincing placebo? Would a different hallucinogen like 4-HO-MET work, where the visual experience comp

Is it even possible to solve the issue of there being no convincing placebo? Would a different hallucinogen like 4-HO-MET work, where the visual experience component is similar, but the visceral effect on consciousness and thought patterns is less pronounced, almost sober like?