6 ms·

I'm no expert but my gist is that light interacts with an enzyme in the electron transport chain (cytochrome c oxidase). CCO is embedded in the inner membrane o

I'm no expert but my gist is that light interacts with an enzyme in the electron transport chain (cytochrome c oxidase). CCO is embedded in the inner membrane of mitochondria, and nitric oxide binds to CCO which temporarily inhibits cellular respiration as a natural metabolic regulation to control oxidative stress. Red and NIR light can photodissociate NO from CCO with the right intensity and wavelength, which restarts cellular respiration and ATP production. The release of NO into the bloodstream can secondarily trigger other chemical pathways involved in vasodilation and reactive oxygen species management. Edit: found a wiki with more details: https://en.wikipedia.org/wiki/Light-emitting_diode_therapy#Photodynamic_(PDT)_mechanism https://en.wikipedia.org/wiki/Light-emitting_diode_therapy#P...

BobaFloutist 2y ago
In general, with a very few exceptions, if the body has a regulatory mechanism there's at least some reason for it, and tinkering with it without understanding it can have unpredictable downsides. >as a natural metabolic regulation to control oxidative stress That sounds like something I'd be very wary of manipulating without a good deal of clinical trials. Isn't oxidative stress one of like three primary hypothesized mechanisms of aging?
- nine_k 2y ago
  The body has regulatory mechanisms formed 100k to 1000k years ago, and some even older. The life was a bit different then, as was humans' mental capacity and knowledge. This is why humans have to actively overcome and sometimes subvert various mechanisms that presume the need to conserve the energy: they hit a gym which the body doesn't like, they limit sugars and fats which the body craves, they consume caffeine, nicotine, or even cocaine to trick the body into working harder and complaining less. Compared to that, hitting the body with some NIR radiation seems very benign. You can get a lot of that just by walking in the sun, and there are no known adverse effects of that, unlike, say the use of the chemical substances. If anything, it's a promising field of research.
  - BobaFloutist 2y ago
    >You can get a lot of that just by walking in the sun, and there are no known adverse effects of that Other than sunburn and skin cancer?
    - nine_k 2y ago
      Sunburns and skin cancer are induced by UV, not NIR light. Put on the protective cream.
    - ankitml 2y ago
      Morning and evening is entirely infrared (80-90 percent with rest of it visible). No UV.

BobaFloutist 2y ago

In general, with a very few exceptions, if the body has a regulatory mechanism there's at least some reason for it, and tinkering with it without understanding it can have unpredictable downsides. >as a natural metabolic regulation to control oxidative stress That sounds like something I'd be very wary of manipulating without a good deal of clinical trials. Isn't oxidative stress one of like three primary hypothesized mechanisms of aging?

nine_k 2y ago
The body has regulatory mechanisms formed 100k to 1000k years ago, and some even older. The life was a bit different then, as was humans' mental capacity and knowledge. This is why humans have to actively overcome and sometimes subvert various mechanisms that presume the need to conserve the energy: they hit a gym which the body doesn't like, they limit sugars and fats which the body craves, they consume caffeine, nicotine, or even cocaine to trick the body into working harder and complaining less. Compared to that, hitting the body with some NIR radiation seems very benign. You can get a lot of that just by walking in the sun, and there are no known adverse effects of that, unlike, say the use of the chemical substances. If anything, it's a promising field of research.
- BobaFloutist 2y ago
  >You can get a lot of that just by walking in the sun, and there are no known adverse effects of that Other than sunburn and skin cancer?
  - nine_k 2y ago
    Sunburns and skin cancer are induced by UV, not NIR light. Put on the protective cream.
  - ankitml 2y ago
    Morning and evening is entirely infrared (80-90 percent with rest of it visible). No UV.