> Except then some years later some assholes point out that mortality didn't actually drop in that targeted population. All that happened is the pathogen mutate

> Except then some years later some assholes point out that mortality didn't actually drop in that targeted population. All that happened is the pathogen mutated to the point neither the test nor the immune system recognize it Seems the incentives are such that you would want to make a virus PCR test using a narrow range of epitopes that you were targeting with the vaccine. That way, if/when you get breakthrough infections you can just say "well I don't see any virus!" See bug, create unit test, fix unit test, no more bug. User complains bug still happens, you ignore because your unit tests still pass.