6 ms·

T1 here. I couldn't read this, even with archive.ph. Here's a more accessible source: https://www.theguardian.com/society/article/2024/aug/11/scientists-hail-

T1 here. I couldn't read this, even with archive.ph. Here's a more accessible source: https://www.theguardian.com/society/article/2024/aug/11/scientists-hail-smart-insulin-responds-changing-blood-sugar-levels-real-time-diabetes?CMP=Share_AndroidApp_Other https://www.theguardian.com/society/article/2024/aug/11/scie... Reddit thread: https://www.reddit.com/r/diabetes_t1/comments/1eppvf5/scientists_hail_smart_insulin_that_responds_to/ https://www.reddit.com/r/diabetes_t1/comments/1eppvf5/scient...

deleted 2y ago
[deleted]
joecool1029 2y ago
Isn't this direct link to pdf? https://www.nature.com/articles/s41586-024-08042-3.pdf https://www.nature.com/articles/s41586-024-08042-3.pdf
bsmartt 2y ago
damn this reddit thread is 3 months old? t1 here as well, and i struggle pretty bad. having been t1 for 20 years or more, i just can't click every article my friends and family send me promising progress for diabetics or potential cures. its just not worth getting my hopes up even when its a reputable outlet making some extraordinary claims. this sounds really promising but yea. its also depressing. its kinda too late to save me even if this comes very soon. which i doubt it will. However, this so called 'smart insulin' sounds to me much more like the shit produced by non-diabetics pancreases. like theres just no way the non-diabetic body is making a hormone that doesnt fully kick in for 90 minutes. that just wouldnt be as resilient and effective as what i witness in the people around me. its insane how they can, for example, eat a tub of ice cream on a whim and not be blasted into the 400s. or just go wild exercising at length on an empty stomach and not have an emergency low sugar.
- haccount 2y ago
  It kick in slowly because standard administration is subcutaneous which isn't a very well vascularized tissue. If you shoot up in your veins or into something more vascular you would have faster onset.
  - protomolecule 2y ago
    >If you shoot up in your veins Which is a sure way to find yourself in a hypoglycemic coma.
    - user_7832 2y ago
      Inhalable insulin (which is also very fast acting) iirc only allows a dose of 2 units. If your sugars are 400mg/dl (22ish mmol/l) one or two doses wouldn't put you into a coma if you knew your sensitivity. I'm pretty sure I've read up T1s talking about using it as such.
      - protomolecule 2y ago
        Sudden drops of the blood glucose level aren't good for health.
  - user_7832 2y ago
    Not only veins, inhalable insulin like Afreeza is also really quick. Unfortunately it only appears to be available in the US (and maybe Canada?), not Europe/Asia from what I last remember.
  - lolc 2y ago
    I participated in studies where they administered insulin and glucose intravenously. It is wild how they can reliably drop my blood sugar from high to low within a few minutes. Subcutaneously this takes me hours to do in a stable way.
- dazc 2y ago
  '...its insane how they can, for example, eat a tub of ice cream on a whim and not be blasted into the 400s.' No such thing as a free lunch, they are just building up insulin resistance with, eventually, Type 2 Diabetes a near certainty in later life.
- pimeys 2y ago
  There's already software that can definitely mitigate these problems you've outlined. I've been using AndroidAPS together with Lyumjev insulin, an insulin pump and a Dexcom system for several years now. Yes, I can go running with an empty stomach and yes, I can have a nice dinner without being in the high 400's... My glucose hasn't really been above 200 for months, and the last time was a leaking tube in the pump. My A1c has been between 5.5 and 5.9% for many years now. There's no need for ambulance to come and rescue me due to hypoglycemia. If you're in any way technical, you should take a look into the solutions for artificial pancreas.
  - terminalcommand 2y ago
    Another T1D here. I do not have a compatible pump with looping. But I'd like to dip my toe into openaps. I use a cgm (libre2). Can I use autotune to tune my carb ratio, basals etc. without looping? How was your experience in this? Do I have to use nightscout to run autotune?
    - pimeys 2y ago
      I've run it against my nightscout data a few times to get insights to my profile. So yes, you should install it somewhere and run a CGM app such as xdrip which can transfer your libre2 data to your nightscout database. So yes, if you are interested on autotune, a nightscout is required for now.

deleted 2y ago

[deleted]

joecool1029 2y ago

Isn't this direct link to pdf? https://www.nature.com/articles/s41586-024-08042-3.pdf https://www.nature.com/articles/s41586-024-08042-3.pdf

bsmartt 2y ago

damn this reddit thread is 3 months old? t1 here as well, and i struggle pretty bad. having been t1 for 20 years or more, i just can't click every article my friends and family send me promising progress for diabetics or potential cures. its just not worth getting my hopes up even when its a reputable outlet making some extraordinary claims. this sounds really promising but yea. its also depressing. its kinda too late to save me even if this comes very soon. which i doubt it will. However, this so called 'smart insulin' sounds to me much more like the shit produced by non-diabetics pancreases. like theres just no way the non-diabetic body is making a hormone that doesnt fully kick in for 90 minutes. that just wouldnt be as resilient and effective as what i witness in the people around me. its insane how they can, for example, eat a tub of ice cream on a whim and not be blasted into the 400s. or just go wild exercising at length on an empty stomach and not have an emergency low sugar.

haccount 2y ago
It kick in slowly because standard administration is subcutaneous which isn't a very well vascularized tissue. If you shoot up in your veins or into something more vascular you would have faster onset.
- protomolecule 2y ago
  >If you shoot up in your veins Which is a sure way to find yourself in a hypoglycemic coma.
  - user_7832 2y ago
    Inhalable insulin (which is also very fast acting) iirc only allows a dose of 2 units. If your sugars are 400mg/dl (22ish mmol/l) one or two doses wouldn't put you into a coma if you knew your sensitivity. I'm pretty sure I've read up T1s talking about using it as such.
    - protomolecule 2y ago
      Sudden drops of the blood glucose level aren't good for health.
- user_7832 2y ago
  Not only veins, inhalable insulin like Afreeza is also really quick. Unfortunately it only appears to be available in the US (and maybe Canada?), not Europe/Asia from what I last remember.
- lolc 2y ago
  I participated in studies where they administered insulin and glucose intravenously. It is wild how they can reliably drop my blood sugar from high to low within a few minutes. Subcutaneously this takes me hours to do in a stable way.
dazc 2y ago
'...its insane how they can, for example, eat a tub of ice cream on a whim and not be blasted into the 400s.' No such thing as a free lunch, they are just building up insulin resistance with, eventually, Type 2 Diabetes a near certainty in later life.
pimeys 2y ago
There's already software that can definitely mitigate these problems you've outlined. I've been using AndroidAPS together with Lyumjev insulin, an insulin pump and a Dexcom system for several years now. Yes, I can go running with an empty stomach and yes, I can have a nice dinner without being in the high 400's... My glucose hasn't really been above 200 for months, and the last time was a leaking tube in the pump. My A1c has been between 5.5 and 5.9% for many years now. There's no need for ambulance to come and rescue me due to hypoglycemia. If you're in any way technical, you should take a look into the solutions for artificial pancreas.
- terminalcommand 2y ago
  Another T1D here. I do not have a compatible pump with looping. But I'd like to dip my toe into openaps. I use a cgm (libre2). Can I use autotune to tune my carb ratio, basals etc. without looping? How was your experience in this? Do I have to use nightscout to run autotune?
  - pimeys 2y ago
    I've run it against my nightscout data a few times to get insights to my profile. So yes, you should install it somewhere and run a CGM app such as xdrip which can transfer your libre2 data to your nightscout database. So yes, if you are interested on autotune, a nightscout is required for now.