10 ms·

TL;DR from the article: The study found that patients prescribed semaglutide had a significantly lower risk for Alzheimer’s disease than those who had taken one

TL;DR from the article: The study found that patients prescribed semaglutide had a significantly lower risk for Alzheimer’s disease than those who had taken one of the seven other diabetes drugs. The results were consistent across gender, age and weight. The biggest difference was seen when comparing patients who took semaglutide to those who took insulin: Semaglutide patients had a 70% lower risk of Alzheimer’s, the study found. Full link to the study itself: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14313 https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz...

SoftTalker 2y ago
Hasn't there been speculation/study along the lines of Alzheimer's being a form of diabetes?
- BJones12 2y ago
  Yes. For example: "Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal" https://www.sciencedirect.com/science/article/pii/S0925443916302150 https://www.sciencedirect.com/science/article/pii/S092544391...
Someone1234 2y ago
With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting.
- AStonesThrow 2y ago
  My PCP agrees that the great results I'm getting on Fen-Phen mean I won't need to switch!
  - Someone1234 2y ago
    GLP-1 have already been on the mass market longer than Fen-Phen (7-years for Fen-Phen Vs. 15+ years, even just Semaglutide has been available longer than Fen-Phen now, and Semaglutide is a third-gen GLP-1). Honestly, this retort can be made about any/all new drugs entering the market. If you had a legitimate retort/critique I'm sure you would have presented it, but this is all we get. This is what happens when you start out with "[thing] is bad" then work backwards to figure out a reason.
    - ikanreed 2y ago
      Ultimately the main reason it's bad right now is it's expensive. Far beyond the amount needed to recoup research investment and far far far far far far far far far beyond what it takes to synthesize. Low-end cost of $1000 a month is a lot. That's an expensive car lease, or half a cheap mortgage.
      - Someone1234 2y ago
        I fully agree. Least of all because it is sold at between $60-200 abroad full-priced. Those countries just have price controls; the pharmacies are still making 80%+ profit margins in those places. Ultimately, a lot of people will literally die because of this greed. That isn't hyperbole.
      - tptacek 2y ago
        These things are priced against their alternatives, and so are almost definitionally less expensive than the status quo ante.
      - rustcleaner 2y ago
        Suddenly it's a national security issue. Suddenly USGov issues emergency production licenses and orders domestically to drop that down to effectively $0.10/kilodose on the market. Suddenly when Denmark (or whoever) whines, USGov sends a cumulative NATO military defense bill, tells them they are the reserve currency, they have bigger nukes, and tough shit next time don't pork barrel the American people. Lots of options for Americans; question is, can we be unprincipled enough to take the steps neccessary? :^)
- deleted 2y ago
  [deleted]
- nordsieck 2y ago
  > With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting. So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight. And while I'll be the first to admit that the proportion of people who could benefit from these drugs is quite large, it's pretty far from everyone.
  - Someone1234 2y ago
    > So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight. It is licensed, tested, and sold as a Type-2 Diabetes medication. Are you claiming it is ineffective for that purpose? Or if you're under the impression that no healthy weight T2 Diabetics exist, I have some news for you... It is also being studied for: opioid addiction, alcoholism, Alzheimer's/Parkinson’s, Cardiovascular Disease, NASH, and PCOS. "So far, I haven't seen evidence" may be more related to what you have read than what is available for you to read.
    - jewayne 2y ago
      Don't dismiss the most important question -- does semaglutide really have any effects outside its current intended use for diabetes and weight loss? In other words, would a thin, metabolically healthy person benefit from taking semaglutide? So far, all of the wonderful benefits from taking the drug seem to be explainable by reduced caloric intake / weight loss / better glucose control in overweight and/or diabetic people.
      - Someone1234 2y ago
        > In other words, would a thin, metabolically healthy person benefit from taking semaglutide? That's what this thread is about; and multiple other studies looking at different diseases/illnesses/addictions. Time will tell. It is currently approved for T2 Diabetes and Obesity.
        2y ago
- thefz 2y ago
  Why would taking a drug you don't need for the rest of your days be a good thing?
  - aantix 2y ago
    what's the alternative? Struggling with food, being extremely overweight the rest of your life, and not being able to play with your kids because of it?
    - thefz 2y ago
      Don't stuff your face with a 2500kcal Oreo and ice cream shake?

SoftTalker 2y ago

Hasn't there been speculation/study along the lines of Alzheimer's being a form of diabetes?

BJones12 2y ago
Yes. For example: "Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal" https://www.sciencedirect.com/science/article/pii/S0925443916302150 https://www.sciencedirect.com/science/article/pii/S092544391...

Someone1234 2y ago

With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting.

AStonesThrow 2y ago
My PCP agrees that the great results I'm getting on Fen-Phen mean I won't need to switch!
- Someone1234 2y ago
  GLP-1 have already been on the mass market longer than Fen-Phen (7-years for Fen-Phen Vs. 15+ years, even just Semaglutide has been available longer than Fen-Phen now, and Semaglutide is a third-gen GLP-1). Honestly, this retort can be made about any/all new drugs entering the market. If you had a legitimate retort/critique I'm sure you would have presented it, but this is all we get. This is what happens when you start out with "[thing] is bad" then work backwards to figure out a reason.
  - ikanreed 2y ago
    Ultimately the main reason it's bad right now is it's expensive. Far beyond the amount needed to recoup research investment and far far far far far far far far far beyond what it takes to synthesize. Low-end cost of $1000 a month is a lot. That's an expensive car lease, or half a cheap mortgage.
    - Someone1234 2y ago
      I fully agree. Least of all because it is sold at between $60-200 abroad full-priced. Those countries just have price controls; the pharmacies are still making 80%+ profit margins in those places. Ultimately, a lot of people will literally die because of this greed. That isn't hyperbole.
    - tptacek 2y ago
      These things are priced against their alternatives, and so are almost definitionally less expensive than the status quo ante.
    - rustcleaner 2y ago
      Suddenly it's a national security issue. Suddenly USGov issues emergency production licenses and orders domestically to drop that down to effectively $0.10/kilodose on the market. Suddenly when Denmark (or whoever) whines, USGov sends a cumulative NATO military defense bill, tells them they are the reserve currency, they have bigger nukes, and tough shit next time don't pork barrel the American people. Lots of options for Americans; question is, can we be unprincipled enough to take the steps neccessary? :^)
deleted 2y ago
[deleted]
nordsieck 2y ago
> With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting. So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight. And while I'll be the first to admit that the proportion of people who could benefit from these drugs is quite large, it's pretty far from everyone.
- Someone1234 2y ago
  > So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight. It is licensed, tested, and sold as a Type-2 Diabetes medication. Are you claiming it is ineffective for that purpose? Or if you're under the impression that no healthy weight T2 Diabetics exist, I have some news for you... It is also being studied for: opioid addiction, alcoholism, Alzheimer's/Parkinson’s, Cardiovascular Disease, NASH, and PCOS. "So far, I haven't seen evidence" may be more related to what you have read than what is available for you to read.
  - jewayne 2y ago
    Don't dismiss the most important question -- does semaglutide really have any effects outside its current intended use for diabetes and weight loss? In other words, would a thin, metabolically healthy person benefit from taking semaglutide? So far, all of the wonderful benefits from taking the drug seem to be explainable by reduced caloric intake / weight loss / better glucose control in overweight and/or diabetic people.
    - Someone1234 2y ago
      > In other words, would a thin, metabolically healthy person benefit from taking semaglutide? That's what this thread is about; and multiple other studies looking at different diseases/illnesses/addictions. Time will tell. It is currently approved for T2 Diabetes and Obesity.
      - 2y ago
thefz 2y ago
Why would taking a drug you don't need for the rest of your days be a good thing?
- aantix 2y ago
  what's the alternative? Struggling with food, being extremely overweight the rest of your life, and not being able to play with your kids because of it?
  - thefz 2y ago
    Don't stuff your face with a 2500kcal Oreo and ice cream shake?