A lot of people will suggest Django, and it's definitely the most popular Python web framework (and therefore the most useful if you're looking for a job using

A lot of people will suggest Django, and it's definitely the most popular Python web framework (and therefore the most useful if you're looking for a job using one). However, Flask is written in a much more open-ended way that gives you a lot more power to create the structure of the application as you see fit. I've been working with it lately, and I'd suggest giving it a try.