9 ms·

Sorry for being nosy, but did you do oral immunotherapy with or without professional support?

by marcod 2y ago

eskibars 2y ago
With. First they did a blood test (instead of a scratch test) to identify possible allergy levels. Then the allergist had us come into the office to take e.g. a few micrograms of peanut powder and watch him for reactions. Then we maintained the dose at home every day for the next couple weeks, taking zyrtec with it to avoid hives, etc. Then we'd go back in, try doubling the dose as a challenge. If he had a bad reaction, we stayed on the same dose another few weeks, and if not, it became the new standard level. Rinse and repeat for about a year until we got to 2 peanuts, 1 cashew, and 1/4 tsp of tahini, which we maintained now for the past ~1.5y. We're due for another blood test and challenge here soon, as the allergist suggested there's a small chance that the immunotherapy could result in the allergies essentially receding
- nathancahill 2y ago
  Our son is allergic to nearly everything (peanuts, nuts, dairy, eggs, sesame, wheat) and we haven't found an allergist willing to work with us. Do you know if there's an age factor for immunotherapy effectiveness? He's 2 1/2 yo.
  - munchbunny 2y ago
    Age is a known factor for oral immunotherapy’s risk and effectiveness, and the commonly cited fuzzy threshold is starting before 2 years of age. The data isn’t that strong, but “start very young” basically has practitioners’ consensus. You have to shop around for allergists willing to do it. Our first allergist told us they weren’t comfortable doing it but it was becoming an increasingly popular option and referred us to several allergists who did it. We’ve also spoken to allergists who were bearish on it. It’s because there’s very little published data.
  - nostrademons 2y ago
    2 1/2 is right in the window, with the general consensus being that the earlier you start, the better the results. Studies found the best results with 1-year-olds, then it exponentially decreases with each year, until there's little benefit with 4+ year olds. We did it with Latitude [1], with the support of our allergist, who had sent his son through them with successful results. It's not covered by insurance, and is expensive in all of time, money, and attention. The field is very new and data is still sparse - our allergist actually was very curious to hear results because he's adapting his practice as new data comes out from actual treatment. [1] https://latitudefoodallergycare.com/ https://latitudefoodallergycare.com/
rahimnathwani 2y ago
I AM NOT A DOCTOR OR OTHER HEALTHCARE PROFESSIONAL I looked into oral immunotherapy for tree nut allergies. There's a paper from 2022: https://onlinelibrary.wiley.com/doi/10.1111/all.15212 https://onlinelibrary.wiley.com/doi/10.1111/all.15212 They did it in a few stages: 1. First three days: test the child with increasing amounts of cashew protein, until the child has a reaction. Use the amount ingested for that reaction, to determine the single highest tolerated dose (SHTD = the maximal amount of cashew protein each patient could tolerate). 2. Next 24 days: the child ingests the SHTD daily. 3. After that: every month, the dose was increased (I think at an in-person visit), and taken at home for the next 30 days. For #1, I looked at the amounts of protein they gave the child. Table S2 (in one of the supporting documents) shows how much they gave on days 1, 2 and 3. Of course they stopped increasing once the child had a reaction. If you convert the amounts of protein into equivalent numbers of whole cashews, then you get: - day 1: start with 1/1800th of a small cashew, increasing up to a fifth of a small cashew. - day 2: 1/5th small cashew, up to 2 small cashews - day 3: 2 small cashews, up to 22 small cashews 22 small cashews is about equivalent to what they want to achieve by the end of the therapy, i.e. if you don't have a reaction after eating that many, you won't have a reaction to a greater quantity. It seems a bit hard to DIY it, because: - The first three days requires very small amounts of cashew protein. At home we don't have either (i) isolated cashew protein, or (ii) tools to measure such small amounts (starting with 0.1mg cashew protein, or 0.5mg cashew). - For the first three days, we'd need to be very vigilant to watch out for a reaction. I don't know whether, in a supervised setting, they'd observe or measure other factors than just an apparent reaction, to make sure the procedure is safe. I AM NOT A DOCTOR OR OTHER HEALTHCARE PROFESSIONAL
- 2-3-7-43-1807 2y ago
  [flagged]
  - deleted 2y ago
    [deleted]
- spike021 2y ago
  For curiosity sake, curious if the tree nut allergy here was typical reactions (hives, nose, etc.)? I have a tree nut "allergy" but doctors always call it more of a "hypersensitivity" because my reactions are usually involving terrible stomach cramps and pain accompanied occasionally by swollen throat (more so for almonds than cashews). I've wondered if it's worth trying to do this myself.

Sorry for being nosy, but did you do oral immunotherapy with or without professional support?

by marcod 2y ago

Sorry for being nosy, but did you do oral immunotherapy with or without professional support?

With. First they did a blood test (instead of a scratch test) to identify possible allergy levels. Then the allergist had us come into the office to take e.g. a few micrograms of peanut powder and watch him for reactions. Then we maintained the dose at home every day for the next couple weeks, taking zyrtec with it to avoid hives, etc. Then we'd go back in, try doubling the dose as a challenge. If he had a bad reaction, we stayed on the same dose another few weeks, and if not, it became the new standard level. Rinse and repeat for about a year until we got to 2 peanuts, 1 cashew, and 1/4 tsp of tahini, which we maintained now for the past ~1.5y. We're due for another blood test and challenge here soon, as the allergist suggested there's a small chance that the immunotherapy could result in the allergies essentially receding

nathancahill 2y ago
Our son is allergic to nearly everything (peanuts, nuts, dairy, eggs, sesame, wheat) and we haven't found an allergist willing to work with us. Do you know if there's an age factor for immunotherapy effectiveness? He's 2 1/2 yo.
- munchbunny 2y ago
  Age is a known factor for oral immunotherapy’s risk and effectiveness, and the commonly cited fuzzy threshold is starting before 2 years of age. The data isn’t that strong, but “start very young” basically has practitioners’ consensus. You have to shop around for allergists willing to do it. Our first allergist told us they weren’t comfortable doing it but it was becoming an increasingly popular option and referred us to several allergists who did it. We’ve also spoken to allergists who were bearish on it. It’s because there’s very little published data.
- nostrademons 2y ago
  2 1/2 is right in the window, with the general consensus being that the earlier you start, the better the results. Studies found the best results with 1-year-olds, then it exponentially decreases with each year, until there's little benefit with 4+ year olds. We did it with Latitude [1], with the support of our allergist, who had sent his son through them with successful results. It's not covered by insurance, and is expensive in all of time, money, and attention. The field is very new and data is still sparse - our allergist actually was very curious to hear results because he's adapting his practice as new data comes out from actual treatment. [1] https://latitudefoodallergycare.com/ https://latitudefoodallergycare.com/

rahimnathwani 2y ago

I AM NOT A DOCTOR OR OTHER HEALTHCARE PROFESSIONAL I looked into oral immunotherapy for tree nut allergies. There's a paper from 2022: https://onlinelibrary.wiley.com/doi/10.1111/all.15212 https://onlinelibrary.wiley.com/doi/10.1111/all.15212 They did it in a few stages: 1. First three days: test the child with increasing amounts of cashew protein, until the child has a reaction. Use the amount ingested for that reaction, to determine the single highest tolerated dose (SHTD = the maximal amount of cashew protein each patient could tolerate). 2. Next 24 days: the child ingests the SHTD daily. 3. After that: every month, the dose was increased (I think at an in-person visit), and taken at home for the next 30 days. For #1, I looked at the amounts of protein they gave the child. Table S2 (in one of the supporting documents) shows how much they gave on days 1, 2 and 3. Of course they stopped increasing once the child had a reaction. If you convert the amounts of protein into equivalent numbers of whole cashews, then you get: - day 1: start with 1/1800th of a small cashew, increasing up to a fifth of a small cashew. - day 2: 1/5th small cashew, up to 2 small cashews - day 3: 2 small cashews, up to 22 small cashews 22 small cashews is about equivalent to what they want to achieve by the end of the therapy, i.e. if you don't have a reaction after eating that many, you won't have a reaction to a greater quantity. It seems a bit hard to DIY it, because: - The first three days requires very small amounts of cashew protein. At home we don't have either (i) isolated cashew protein, or (ii) tools to measure such small amounts (starting with 0.1mg cashew protein, or 0.5mg cashew). - For the first three days, we'd need to be very vigilant to watch out for a reaction. I don't know whether, in a supervised setting, they'd observe or measure other factors than just an apparent reaction, to make sure the procedure is safe. I AM NOT A DOCTOR OR OTHER HEALTHCARE PROFESSIONAL

2-3-7-43-1807 2y ago
[flagged]
- deleted 2y ago
  [deleted]
spike021 2y ago
For curiosity sake, curious if the tree nut allergy here was typical reactions (hives, nose, etc.)? I have a tree nut "allergy" but doctors always call it more of a "hypersensitivity" because my reactions are usually involving terrible stomach cramps and pain accompanied occasionally by swollen throat (more so for almonds than cashews). I've wondered if it's worth trying to do this myself.