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That is not true. It is the interaction of nicotine with various monoamine oxidase inhibitors that makes tobacco smoking addictive, to an extent that it could b
by brobdingnag_pp 2y ago
That is not true. It is the interaction of nicotine with various monoamine oxidase inhibitors that makes tobacco smoking addictive, to an extent that it could be stated that it is the MAOIs entirely causing the addictive behaviour: the exact same MAOIs are also found in coffee, after all.
Why are nicotine pouches and vapes addictive, then? The answer lies in the flavourings, which themselves have psychoactive properties, likely also through MAO inhibition.
- boxed 2y agoYou will have to supply something to back up such a wild statement. Nicotine has been shown to be extremely addictive all the way from humans down to single neurons in a petri dish, for decades.
- camgunz 2y agoGod this Gwern junk will never die. There's tons [0] of evidence that nicotine is addictive on its own. > Why are nicotine pouches and vapes addictive It's the nicotine. [0]: https://duckduckgo.com/?q=nicotine+addictive+site%3Anih.gov&t=ffip&ia=web https://duckduckgo.com/?q=nicotine+addictive+site%3Anih.gov&...
- Aerroon 2y agoI'm not here to argue, but all top 5 links for me are about smoking. I've not heard of people being addicted to nicotine patches for example, especially non-smokers.
- boston_clone 2y agohttps://www.fda.gov/tobacco-products/health-effects-tobacco-use/nicotine-why-tobacco-products-are-addictive https://www.fda.gov/tobacco-products/health-effects-tobacco-...
- camgunz 2y agoNicotine Addiction: Neurobiology and Mechanism: https://pubmed.ncbi.nlm.nih.gov/32322429/ https://pubmed.ncbi.nlm.nih.gov/32322429/ Neurophysiology of Nicotine Addiction: https://pubmed.ncbi.nlm.nih.gov/22454789/ https://pubmed.ncbi.nlm.nih.gov/22454789/
- brobdingnag_pp 2y agohttps://link.springer.com/article/10.1007/BF02247412 https://link.springer.com/article/10.1007/BF02247412
- ck425 2y agoI looked into this previously, though it was a while ago so I no longer have the sources to hand. Nicotine is still addictive on it's own but when given to non-smokers in a non-tobacco form it's notably less addictive than smoking. Still addictive but far closer to coffee than cigarettes. Some of this can be explained by different consumptions methods. For example in lozenges, gum and patches nicotine enters the bloodstream much slower than smoking or vaping so even if you consume the same overall amount the peak is lower slowing adaption. But that couldn't explain it entirely.
- boston_clone 2y agoNo, it's because nicotine is an addictive chemical. https://www.fda.gov/tobacco-products/health-effects-tobacco-use/nicotine-why-tobacco-products-are-addictive https://www.fda.gov/tobacco-products/health-effects-tobacco-...