4 ms·

I'm eagerly awaiting cyclodextrin based treatments, that can potentially remove the plaque and cholesterol buildup. There's so much to be positive about at the

I'm eagerly awaiting cyclodextrin based treatments, that can potentially remove the plaque and cholesterol buildup. There's so much to be positive about at the moment.

tcbawo 3y ago
Do you have any links to what you’re referring to? From what I dug up, early results had not shown effectiveness with reversing atherosclerosis.
- forgetfreeman 3y ago
  According to a thing I read a while back on the AHA website the only thing known to reverse atherosclerosis is interment in a concentration camp. :/
  - heyitsguay 3y ago
    Seeking cofounder for a disruptive, high-margin healthcare startup providing new treatments with deep historical roots.
    - rpastuszak 3y ago
      Keep talking like that and you might end up on the cover of Forbes
- go_prodev 3y ago
  It appears to be a pretty active area of research on Google Scholar, which is where I first learned about Cyclodextrin for heart disease. Here are some of the links I've read recently, which sound promising to me (a non-expert in this field). Microarray patches to deal with bio-availability of Cyclodextrin: https://www.sciencedirect.com/science/article/pii/S0144861723006598 https://www.sciencedirect.com/science/article/pii/S014486172... Cholrem company has a commercial product Cavadex, which they claim can reverse arterial plaque: https://www.cholrem.com/ https://www.cholrem.com/ Cyclarity Therapeutics have a Cyclodextrin candidate drug they are hoping to start trials on next year: https://cyclaritytx.com/our-science/ https://cyclaritytx.com/our-science/ Cyclarity (formerly Underdog Pharmaceuticals) published an article on their technology to use Cyclodextrin molecules to encapsulate "toxic biomolecules" including 7-ketocholesterol which they believe is linked to atherosclerosis and macular degeneration. I think this might be the approach they are using with their candidate drug linked above. https://www.sciencedirect.com/science/article/pii/S0378517321003276 https://www.sciencedirect.com/science/article/pii/S037851732... I get the impression that Cyclodextrins are far from perfect, but at least there is some hope for non-invasive treatments in future.

I'm eagerly awaiting cyclodextrin based treatments, that can potentially remove the plaque and cholesterol buildup. There's so much to be positive about at the moment.

tcbawo 3y ago

Do you have any links to what you’re referring to? From what I dug up, early results had not shown effectiveness with reversing atherosclerosis.

forgetfreeman 3y ago
According to a thing I read a while back on the AHA website the only thing known to reverse atherosclerosis is interment in a concentration camp. :/
- heyitsguay 3y ago
  Seeking cofounder for a disruptive, high-margin healthcare startup providing new treatments with deep historical roots.
  - rpastuszak 3y ago
    Keep talking like that and you might end up on the cover of Forbes
go_prodev 3y ago
It appears to be a pretty active area of research on Google Scholar, which is where I first learned about Cyclodextrin for heart disease. Here are some of the links I've read recently, which sound promising to me (a non-expert in this field). Microarray patches to deal with bio-availability of Cyclodextrin: https://www.sciencedirect.com/science/article/pii/S0144861723006598 https://www.sciencedirect.com/science/article/pii/S014486172... Cholrem company has a commercial product Cavadex, which they claim can reverse arterial plaque: https://www.cholrem.com/ https://www.cholrem.com/ Cyclarity Therapeutics have a Cyclodextrin candidate drug they are hoping to start trials on next year: https://cyclaritytx.com/our-science/ https://cyclaritytx.com/our-science/ Cyclarity (formerly Underdog Pharmaceuticals) published an article on their technology to use Cyclodextrin molecules to encapsulate "toxic biomolecules" including 7-ketocholesterol which they believe is linked to atherosclerosis and macular degeneration. I think this might be the approach they are using with their candidate drug linked above. https://www.sciencedirect.com/science/article/pii/S0378517321003276 https://www.sciencedirect.com/science/article/pii/S037851732... I get the impression that Cyclodextrins are far from perfect, but at least there is some hope for non-invasive treatments in future.