6 ms·

Is there any way to prove that the arrow of causality is the other way? (i.e., depression causes damage to mitochondria).

judge2020 4y ago
[flagged]
- reactspa 4y ago
  > Shameless chatgpt response LOL. Follow on question for anyone reading this: Is there any evidence that pranayam (yogic breathing exercises) can heal mitochondria?
- moremetadata 4y ago
  Mitochondria need Manganese Super Oxide Dismutase (MnSOD) to mitigate the harmful effects of free radicals/reactive oxygen species (ROS). Manganese (Mn) and Iron (Fe) share the same gut transporters and other transporters in the body (Divalent Metal Transporter). Fe based ROS generate the most heat in our bodies, which is why we tend not to feel the cold when young, but do when we age. When looking at the risks of too much manganese like Parkinson's, I wonder if, when we are born, are our Mn levels so high our baby/toddler/child like lack of coordination is due to excess amounts of Mn in the body? Main risks of excess Mn is from non ingested routes into the body, like inhalation and injection including perinatal (food) drips in hospitals of all places!!! Mn also does alot more in the body besides becoming MnSOD, so is this study actually witnessing the effects of not enough Manganese in the diet? The Mediterranean diet is high in seafood. Coastal waters have the highest concentration of Manganese which is why I would use mussels for my source of Omega-3 over deep sea fish, because the mussels will have a higher concentration of Manganese than the deep sea fish. Some studies suggest glycine can increase the lifespan/duration of mitochondria, so are these immune system responses like the one mentioned here an indication of an incomplete or unbalanced diet?
  - ghotli 4y ago
    I like these sorts of comments on HN, just when they're substantiated with citations I can verify independently. Otherwise it's not much more useful than noise.
- throwaway1851 4y ago
  Chatgpt has such a recognizable tone. I recognized it partway through the the first sentence, but I can’t quite put my finger on what tipped me off.
  - buu700 4y ago
    Off the top of my head, I think it's a few things: * Neutral/textbook-like personality * Lack of first-person pronouns * Lack of any indication of relevant experience/credentials * Lack of any tangents, stories, or any other attempt to relate with the reader * High confidence/authoritativeness/matter-of-factness * Lack of external sources or URLs * Lack of any deep connection to the context of the conversation (such as a tie-in to other aspects of the thread, a reference to some aspect of HN, a reference to current events / pop culture, etc.) * At least in this case, an overly literal interpretation of the question (despite being phrased as such, most humans wouldn't have interpreted reactspa's comment as a yes-or-no question) Overall, it's not bad at answering questions, but the fact that it doesn't attempt to impersonate humans by default can give its output a bit of an uncanny valley feeling.
graphe 4y ago
This is the similar with vitamin d and COVID. They found out COVID depleted vitamin d.
- moremetadata 4y ago
  or did the immune system response deplete vitamin d?
  - jvm___ 4y ago
    Or did you have low vitamin D, because your elderly and live in a home and don't get enough sunlight.
    - ralusek 4y ago
      Or is sufficient vitamin D highly correlated with eating a balanced diet and engaging in exercise outside?
    - mrcode007 4y ago
      Most of vitamin D in your body is synthesized from cholesterol and the extra boost you get from sun exposure is by UVB breaking cholesterol into D3. This mechanism occurs naturally with or without sun’s help.
    - moremetadata 4y ago
      My tests and comments in a British national newspaper triggered this to occur. https://www.sciencedirect.com/science/article/abs/pii/S0960076021001102 https://www.sciencedirect.com/science/article/abs/pii/S09600... I know a reasonable amount about vitamin D to say the least and I dont agree with all the experts. For example when discussing food cravings related to vitamin D, a PhD expert and studying vit d suggested it was folates due to the solar irradiance exposure. UV destroys folates in the body. I wasnt so sure then and I'm still not so sure this is the sole answer. I think what I told them was correct and I've since seen studies from the 1950's which would back up my assertion. In fact when considering folates create formaldehyde which is cancerous, is the reduction in cancer seen with higher levels of Vit D due to obtaining Vit D from sunshine?
_9omd 4y ago
Okay, but then what causes depression? It seems more likely that a range of environmental, lifestyle, and genetic factors cause both depression and mitochondrial damage.
- alfor 4y ago
  lack of infrared is what cause the damage. mitochondria need infrared to make melatonin(remove free radicals from combustion) Without infrared (living inside) we are in constant inflammation, especially the mitochondria The research is solid, but it’s mostly ignored.
  - Earw0rm 4y ago
    Filament and halogen lamps produce masses of infrared. Narrowband and low-energy lights (fluorescent and LED), not so much.
im3w1l 4y ago
I could see it. Depression, leading to unhealthy eating habits leading to mitochondrial stress and deterioration.

judge2020 4y ago

[flagged]

reactspa 4y ago
> Shameless chatgpt response LOL. Follow on question for anyone reading this: Is there any evidence that pranayam (yogic breathing exercises) can heal mitochondria?
moremetadata 4y ago
Mitochondria need Manganese Super Oxide Dismutase (MnSOD) to mitigate the harmful effects of free radicals/reactive oxygen species (ROS). Manganese (Mn) and Iron (Fe) share the same gut transporters and other transporters in the body (Divalent Metal Transporter). Fe based ROS generate the most heat in our bodies, which is why we tend not to feel the cold when young, but do when we age. When looking at the risks of too much manganese like Parkinson's, I wonder if, when we are born, are our Mn levels so high our baby/toddler/child like lack of coordination is due to excess amounts of Mn in the body? Main risks of excess Mn is from non ingested routes into the body, like inhalation and injection including perinatal (food) drips in hospitals of all places!!! Mn also does alot more in the body besides becoming MnSOD, so is this study actually witnessing the effects of not enough Manganese in the diet? The Mediterranean diet is high in seafood. Coastal waters have the highest concentration of Manganese which is why I would use mussels for my source of Omega-3 over deep sea fish, because the mussels will have a higher concentration of Manganese than the deep sea fish. Some studies suggest glycine can increase the lifespan/duration of mitochondria, so are these immune system responses like the one mentioned here an indication of an incomplete or unbalanced diet?
- ghotli 4y ago
  I like these sorts of comments on HN, just when they're substantiated with citations I can verify independently. Otherwise it's not much more useful than noise.
throwaway1851 4y ago
Chatgpt has such a recognizable tone. I recognized it partway through the the first sentence, but I can’t quite put my finger on what tipped me off.
- buu700 4y ago
  Off the top of my head, I think it's a few things: * Neutral/textbook-like personality * Lack of first-person pronouns * Lack of any indication of relevant experience/credentials * Lack of any tangents, stories, or any other attempt to relate with the reader * High confidence/authoritativeness/matter-of-factness * Lack of external sources or URLs * Lack of any deep connection to the context of the conversation (such as a tie-in to other aspects of the thread, a reference to some aspect of HN, a reference to current events / pop culture, etc.) * At least in this case, an overly literal interpretation of the question (despite being phrased as such, most humans wouldn't have interpreted reactspa's comment as a yes-or-no question) Overall, it's not bad at answering questions, but the fact that it doesn't attempt to impersonate humans by default can give its output a bit of an uncanny valley feeling.

graphe 4y ago

This is the similar with vitamin d and COVID. They found out COVID depleted vitamin d.

moremetadata 4y ago
or did the immune system response deplete vitamin d?
- jvm___ 4y ago
  Or did you have low vitamin D, because your elderly and live in a home and don't get enough sunlight.
  - ralusek 4y ago
    Or is sufficient vitamin D highly correlated with eating a balanced diet and engaging in exercise outside?
  - mrcode007 4y ago
    Most of vitamin D in your body is synthesized from cholesterol and the extra boost you get from sun exposure is by UVB breaking cholesterol into D3. This mechanism occurs naturally with or without sun’s help.
  - moremetadata 4y ago
    My tests and comments in a British national newspaper triggered this to occur. https://www.sciencedirect.com/science/article/abs/pii/S0960076021001102 https://www.sciencedirect.com/science/article/abs/pii/S09600... I know a reasonable amount about vitamin D to say the least and I dont agree with all the experts. For example when discussing food cravings related to vitamin D, a PhD expert and studying vit d suggested it was folates due to the solar irradiance exposure. UV destroys folates in the body. I wasnt so sure then and I'm still not so sure this is the sole answer. I think what I told them was correct and I've since seen studies from the 1950's which would back up my assertion. In fact when considering folates create formaldehyde which is cancerous, is the reduction in cancer seen with higher levels of Vit D due to obtaining Vit D from sunshine?

_9omd 4y ago

Okay, but then what causes depression? It seems more likely that a range of environmental, lifestyle, and genetic factors cause both depression and mitochondrial damage.

alfor 4y ago
lack of infrared is what cause the damage. mitochondria need infrared to make melatonin(remove free radicals from combustion) Without infrared (living inside) we are in constant inflammation, especially the mitochondria The research is solid, but it’s mostly ignored.
- Earw0rm 4y ago
  Filament and halogen lamps produce masses of infrared. Narrowband and low-energy lights (fluorescent and LED), not so much.

im3w1l 4y ago

I could see it. Depression, leading to unhealthy eating habits leading to mitochondrial stress and deterioration.