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Thanks for everyone's thoughtful responses. I'm researching Responsive Web Design as an option for a large e-commerce site. But for me, for a large site with a

• stc 15y ago
  You can do much more than just changing the column numbers or width, you can alter any styles.
• rimantas 15y ago
  You don't need to take "all" screen sizes into consideration. Just choose a few breaking points roughly equivalent to desktop, tablet and phone screens. This combined with fluid designs will let you to accommodate most of the variations quite well.
• danneu 15y ago
  There are frameworks like Skeleton and Zurb's Foundation that handle the media queries and resizing/restyling for you, you just have to use their markup. And what they do out of the box is pretty much enough unless you want to hand-tweak a style down the road. Also, responsive design doesn't have to be about getting your website to work on your 2001 Nokia brick's display. A good first step in responsive design is just to take advantage of the full width of the device your user is using up until a point. A lot of websites I view from my netbook could take advantage of just one media query: a full-sized design for large screens and then a fluid width design for anything smaller. I find a lot of websites give me a horizontal scrollbar on the 10' screen.