6 ms·
I worry this comment is overly dismissive of criticisms and overly optimistic about potential positives. On medicine topics I think it is important to try remai
by thornjm 4y ago
I worry this comment is overly dismissive of criticisms and overly optimistic about potential positives. On medicine topics I think it is important to try remain objective.
1. On DXM being an NMDA antagonist:
At high concentration DXM is an NMDA antagonist and AXS-05 does dramatically increases DXM concentration [0] (slide 6). It is not clear to me why we should "ignore anyone" who makes this comparison?
2. On AXS-05 having a wide array of receptor targets:
Almost all psychoactive drugs have some affinity for many receptors (just wikipedia any anti-psychotic e.g. [1]). Are any of the targets mentioned clinically significant at therapeutic concentrations?
[0] https://axsometherapeuticsinc.gcs-web.com/static-files/4a50801a-d8f7-489b-99dd-2d2c28828471 https://axsometherapeuticsinc.gcs-web.com/static-files/4a508...
[1] https://en.wikipedia.org/wiki/Olanzapine https://en.wikipedia.org/wiki/Olanzapine
- PragmaticPulp 4y ago> It is not clear to me why we should "ignore anyone" who makes this comparison? I said that we should ignore people trying to compare this drug to recreational use. It's likely that NMDA is in play and I'm not suggesting otherwise. I wanted to highlight that DXM has significant affinities for other targets like the serotonin transporter that could also explain the efficacy, so it's a mistake to focus on one receptor as the single answer.