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I don’t know why they write that, but one of the papers they quote for that claim reported success with samples up to 19 years old and in turn cites a paper tha
by sammax 4y ago
I don’t know why they write that, but one of the papers they quote for that claim reported success with samples up to 19 years old and in turn cites a paper that reported “genotyping whole-genome-amplified DNA” from up to 25 year old blood spots. I don’t know what this means exactly, it definitely isn’t the methylenation thing, but I think it’s a good indication that blood much older than a decade is viable. Both of these papers also report no differences in results between older and younger samples, only between different extraction methods and amounts.
- jjcon 4y ago> 19 years old and in turn cites a paper that reported “genotyping whole-genome-amplified DNA” from up to 25 year old blood spots You are notably omitting that those specific samples were kept at -20° C. I don’t know any country that does that for their Guthrie samples.
- sammax 4y agoI did actually miss that. But my point is that none of the papers established a limit at 10 years and it’s not clear at all how the authors came up with that number.