Keep in mind this is study is evaluating the claims that microdosing lead to specific outcomes such as enhanced wellness and cognitive enhancements, which peopl

Keep in mind this is study is evaluating the claims that microdosing lead to specific outcomes such as enhanced wellness and cognitive enhancements, which people seek out while microdosing. That's different from using strong doses of psychedelics to, say for example, break entrenched thought patterns (addiction, depression, OCD). In the former case, a positive outcome is expected and therefore negative outcomes are in a sense less tolerable, especially since a false positive would lead to people repeatedly microdosing over an extended period of time, to their long-term detriment. In the latter case, a "negative experience" does not preclude getting the desired results. And an acute negative experience in a one-time dose may be tolerable when contrasted with the long-term severity of the pathology it is meant to treat.