4 ms·

No, stop staying this foolishness. In dense cities like NY, I would say at least 20% of the city is infected right now. Workers. People on the street. The subwa

No, stop staying this foolishness. In dense cities like NY, I would say at least 20% of the city is infected right now. Workers. People on the street. The subway is disgusting, there is at least one infected person per carriage coughing over everyone and refusing to wear a mask. You walk around and hear that infected lung with light mucus cough. It’s everywhere. Unless we get proper proper sterilizing vaccines, the world is going to be in a cycle of getting sick from it every few months. This is serious and infectious like nothing on earth. I am tired of the selfishness of people having an attitude that it’s not a big deal. At this point the vax we had is for something that doesn’t exist anymore. There is no long lasting natural resistance. We need new tech and widespread adoption. If people are going to go out symptomatic and infected and spread an r=17.5 virus, and there really is nothing we can do to stop them, we need much better tech to save us.

internet_user 4y ago
Immunity is likely long term. There was evidence of a bone marrow compartment formation after primary infection in the early days of the pandemic, maybe even as early as 2020. It continues to be supported. Latest: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2794167 https://jamanetwork.com/journals/jamanetworkopen/fullarticle... "This work provides further evidence of sustained immune response in children up to 1 year after primary SARS-CoV-2 infection." More details on the mechanism: https://pubmed.ncbi.nlm.nih.gov/34030176 https://pubmed.ncbi.nlm.nih.gov/34030176 "Overall, our results indicate that mild infection with SARS-CoV-2 induces robust antigen-specific, long-lived humoral immune memory in humans." Follow the science. There is no need to panic.
- randomhodler84 4y ago
  Yes, however BA.5 is another beast. Post infection immunity lasts in the order of weeks it would appear.
  - akkawwakka 4y ago
    Immunity to infection ≠ immunity to serious disease. The epitopes that drive long-lived memory are fairly well conserved.
    - randomhodler84 4y ago
      I just wanna go out in public and not get sick. It’s happened too many times now.
      - t-3 4y ago
        If the vaccine isn't stopping you from getting sick now, why would it stop you from getting sick if more people took it? Does not compute.
        sn9 4y ago
        Because the vaccines still slow transmission and more people getting vaccinated would slow transmission even more, lowering one's risk of getting infected as well as the severity of the infection.
        xyzzyz 4y ago
        Were you not getting sick before Covid? Lucky you, I got colds a couple times a year, even more often after my kids started attending school. Covid is just another cold for me, why should I care?
        randomhodler84 4y ago
        No not really. And I am childfree forever so I don’t have to put up with the little pestilence beasts and their Petri dish school crud. Very lucky! Some occasional subway crud but when you catch COVID over and over again you lose weeks of your life. Also Because colds don’t cause long term damage, blood clots, etc. This isn’t another cold. It could be mild, or you could wind up with complications from blood clots and inflammation for the next year, more… That losing your taste? That’s brain damage, buster. Yeah just a cold…
TeeMassive 4y ago
> In dense cities like NY, I would say at least 20% of the city is infected right now. Workers. People on the street. The subway is disgusting, there is at least one infected person per carriage coughing over everyone and refusing to wear a mask. You walk around and hear that infected lung with light mucus cough. It’s everywhere. If you are to insult people's intelligence then don't use your own germophobic anecdotal perception of the world as a credible epidemiological source. > Unless we get proper proper sterilizing vaccines, the world is going to be in a cycle of getting sick from it every few months. I get it that you're not familiar with most respiratory viruses. > I am tired of the selfishness of people having an attitude that it’s not a big deal. Imposing a medical procedure for your own safety is also a form of selfishness that lead to abuse in the recent past (see Jacobson v. Massachusetts and how it lead to Buck v. Bell) > There is no long lasting natural resistance. We need new tech and widespread adoption. Coronaviruses are know to change very quickly and this is why they escape immunity. Tech is not magic and won't change that fact of life. A universal coronavirus vaccine is a pipe dream.
- randomhodler84 4y ago
  I’d say virusaphobic. I have been sicker from others in the last year than in 2020 and earlier. I’ve lost a lot of life this past year. So what are we going do? Big city life is going to be unbelievably poor unless we solve this problem.
- cameldrv 4y ago
  Bob Wachter, who is the chair of medicine at UCSF periodically publishes the UCSF asymptomatic test positive rate. Everyone who is admitted to UCSF takes a Covid test. This rate is the fraction of people who are admitted without Covid symptoms, that test positive. IMO this is a very good number because it's a somewhat randomized population that is being tested in a controlled way, without too much bias. The latest number he posted, from July 3, was 6.5% [1]. This means roughly 1 in 15 people you come across in San Francisco is positive for Covid. If you're on a crowded bus or train car, there will be multiple Covid positive people on it, and likely one that is contagious. If you regularly take transit and aren't wearing a really excellent mask, it's pretty likely you'll catch it over the course of a month or two. Back to anecdotes, about 70% of the people I know that fit this description and ride transit in a big city without a mask have gotten symptomatic Covid in the past 3 months. All of them boosted btw. [1] https://twitter.com/Bob_Wachter/status/1543780608744165376 https://twitter.com/Bob_Wachter/status/1543780608744165376
rayiner 4y ago
Well maybe try moving out of such a densely packed disease trap? Out here in the exurbs I don’t know a single person for whom covid has been any more inconvenient than a cold (since vaccines became widely available). I’m no anti-vaxxer. I had it, got vaxxed anyway just in case, wore my masks, etc. Like most people, I’m done now. If you want to go live in a bubble be my guest.
- randomhodler84 4y ago
  I don’t not have that luxury to move. It’s not about me in a bubble. It’s about humanity and a painful existence of pestilence. You might be “done” with it. Humanity is not. Virus is not. A bubble is ignoring one of the greatest threats to our civilization today.
- sn9 4y ago
  That implies we should simply empty the world's cities which I hope you recognize is not a serious or pragmatic alternative to simply vaccinating more. We could just vaccinate our way until Covid transmission rates fall enough that we don't have to worry about it. Congrats on living in the middle of nowhere, but that's a bubble of a different sort.

internet_user 4y ago

Immunity is likely long term. There was evidence of a bone marrow compartment formation after primary infection in the early days of the pandemic, maybe even as early as 2020. It continues to be supported. Latest: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2794167 https://jamanetwork.com/journals/jamanetworkopen/fullarticle... "This work provides further evidence of sustained immune response in children up to 1 year after primary SARS-CoV-2 infection." More details on the mechanism: https://pubmed.ncbi.nlm.nih.gov/34030176 https://pubmed.ncbi.nlm.nih.gov/34030176 "Overall, our results indicate that mild infection with SARS-CoV-2 induces robust antigen-specific, long-lived humoral immune memory in humans." Follow the science. There is no need to panic.

randomhodler84 4y ago
Yes, however BA.5 is another beast. Post infection immunity lasts in the order of weeks it would appear.
- akkawwakka 4y ago
  Immunity to infection ≠ immunity to serious disease. The epitopes that drive long-lived memory are fairly well conserved.
  - randomhodler84 4y ago
    I just wanna go out in public and not get sick. It’s happened too many times now.
    - t-3 4y ago
      If the vaccine isn't stopping you from getting sick now, why would it stop you from getting sick if more people took it? Does not compute.
      - sn9 4y ago
        Because the vaccines still slow transmission and more people getting vaccinated would slow transmission even more, lowering one's risk of getting infected as well as the severity of the infection.
      - xyzzyz 4y ago
        Were you not getting sick before Covid? Lucky you, I got colds a couple times a year, even more often after my kids started attending school. Covid is just another cold for me, why should I care?
        randomhodler84 4y ago
        No not really. And I am childfree forever so I don’t have to put up with the little pestilence beasts and their Petri dish school crud. Very lucky! Some occasional subway crud but when you catch COVID over and over again you lose weeks of your life. Also Because colds don’t cause long term damage, blood clots, etc. This isn’t another cold. It could be mild, or you could wind up with complications from blood clots and inflammation for the next year, more… That losing your taste? That’s brain damage, buster. Yeah just a cold…

TeeMassive 4y ago

> In dense cities like NY, I would say at least 20% of the city is infected right now. Workers. People on the street. The subway is disgusting, there is at least one infected person per carriage coughing over everyone and refusing to wear a mask. You walk around and hear that infected lung with light mucus cough. It’s everywhere. If you are to insult people's intelligence then don't use your own germophobic anecdotal perception of the world as a credible epidemiological source. > Unless we get proper proper sterilizing vaccines, the world is going to be in a cycle of getting sick from it every few months. I get it that you're not familiar with most respiratory viruses. > I am tired of the selfishness of people having an attitude that it’s not a big deal. Imposing a medical procedure for your own safety is also a form of selfishness that lead to abuse in the recent past (see Jacobson v. Massachusetts and how it lead to Buck v. Bell) > There is no long lasting natural resistance. We need new tech and widespread adoption. Coronaviruses are know to change very quickly and this is why they escape immunity. Tech is not magic and won't change that fact of life. A universal coronavirus vaccine is a pipe dream.

randomhodler84 4y ago
I’d say virusaphobic. I have been sicker from others in the last year than in 2020 and earlier. I’ve lost a lot of life this past year. So what are we going do? Big city life is going to be unbelievably poor unless we solve this problem.
cameldrv 4y ago
Bob Wachter, who is the chair of medicine at UCSF periodically publishes the UCSF asymptomatic test positive rate. Everyone who is admitted to UCSF takes a Covid test. This rate is the fraction of people who are admitted without Covid symptoms, that test positive. IMO this is a very good number because it's a somewhat randomized population that is being tested in a controlled way, without too much bias. The latest number he posted, from July 3, was 6.5% [1]. This means roughly 1 in 15 people you come across in San Francisco is positive for Covid. If you're on a crowded bus or train car, there will be multiple Covid positive people on it, and likely one that is contagious. If you regularly take transit and aren't wearing a really excellent mask, it's pretty likely you'll catch it over the course of a month or two. Back to anecdotes, about 70% of the people I know that fit this description and ride transit in a big city without a mask have gotten symptomatic Covid in the past 3 months. All of them boosted btw. [1] https://twitter.com/Bob_Wachter/status/1543780608744165376 https://twitter.com/Bob_Wachter/status/1543780608744165376

rayiner 4y ago

Well maybe try moving out of such a densely packed disease trap? Out here in the exurbs I don’t know a single person for whom covid has been any more inconvenient than a cold (since vaccines became widely available). I’m no anti-vaxxer. I had it, got vaxxed anyway just in case, wore my masks, etc. Like most people, I’m done now. If you want to go live in a bubble be my guest.

randomhodler84 4y ago
I don’t not have that luxury to move. It’s not about me in a bubble. It’s about humanity and a painful existence of pestilence. You might be “done” with it. Humanity is not. Virus is not. A bubble is ignoring one of the greatest threats to our civilization today.
sn9 4y ago
That implies we should simply empty the world's cities which I hope you recognize is not a serious or pragmatic alternative to simply vaccinating more. We could just vaccinate our way until Covid transmission rates fall enough that we don't have to worry about it. Congrats on living in the middle of nowhere, but that's a bubble of a different sort.