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From the artcile: "The numbers were small — 13 metformin-exposed boys were born with genital defects. But after the researchers adjusted for factors including p
by lippel82 4y ago
From the artcile: "The numbers were small — 13 metformin-exposed boys were born with genital defects. But after the researchers adjusted for factors including parental ages and maternal smoking status, they found a 3.39-fold rise in the odds of a genital defect. “The rate per se was surprisingly high,” Wensink says."
- ovi256 4y ago> after the researchers adjusted for factors including parental ages and maternal smoking status The exact adjustments made can change the solidity of the finding into anything from "rock solid" to "complete trash". Seemingly solid studies are routinely trashed by third party method reviewers that the initial peer reviewers missed. So we'll know better when they get around to it.
- carlmr 4y ago>But after the researchers adjusted for factors including parental ages and maternal smoking status, they found a 3.39-fold rise in the odds of a genital defect If they didn't adjust for obesity, then it's really pointless to attribute this to the drug. Age and smoking status is not enough.
- rat9988 4y agoWhy would you assume they didn't? They most likely did.
- carlmr 4y agoFrom the quote it says they only adjusted for age and smoking.
- tssva 4y agoThe quote says the factors included age and smoking not that they only included age and smoking.
- carlmr 4y agoI did indeed not read that properly. I'd have to check the actual publication. It's at least suspicious that they don't mention it, since obesity is probably the first thing you should think of when saying diabetes.
- darawk 4y agoAdjusting for confounders on an n of 13 is statistically ridiculous.
- carlmr 4y agoIt's not n=13 it's 13 with genetic defects. Also not adjusting for confounders is statistically ridiculous. As well as n=13 studies.
- orwin 4y agoi'll call n the total number of patients. if n * 9 / 1000 = 13, you'll find out that n is around 1400, which is a pretty high number in discovery studies. Maybe not for diabetes though, i remember hosting anonymized data from a lot more patients two years ago, i felt this was THE subject all the medical founding was put into (that and air quality and its effect studies).