Yeah I just linked that study because it was looking at QALY which is an aggregate metric so it should in some sense take into account the effects of overdiagno

Yeah I just linked that study because it was looking at QALY which is an aggregate metric so it should in some sense take into account the effects of overdiagnosis even if overdiagnosis is not explicitly handled. Here is another study looking at all-cause mortality, which again does implicitly handle overdiagnosis. https://www.ajronline.org/doi/full/10.2214/AJR.14.12666 https://www.ajronline.org/doi/full/10.2214/AJR.14.12666