Other good answers are here about additional mutations occurring, making the cells no longer receptive. Another reason is that receiving CAR-T itself is quite r

Other good answers are here about additional mutations occurring, making the cells no longer receptive. Another reason is that receiving CAR-T itself is quite risky. Almost everyone experiences some level of neurotoxicity, decreased cognition and more. It is my hope that these negative effects caused by the treatment will vanish, as CAR-T itself is pretty amazing.