6 ms·
Bioengineer here able to chime in with niche expertise. Cartilage is and has been a holy grail in biomedical engineering but is very difficult to grow and trans
by vervez 5y ago
Bioengineer here able to chime in with niche expertise. Cartilage is and has been a holy grail in biomedical engineering but is very difficult to grow and transplant. There have been some successful neo-cartilage projects but integrating that into a defect and successfully integrating with host cartilage is the problem. The boundary of the defect actually has electronegative components that actively oppose integration of host and transplant (synthetic) cartilage. I think the most likely solution won't be a tissue-engineered transplant but rather an active cellular component that appropriately responds, and builds upon, this negative feedback cycle via cellular programming.
- xwdv 5y agoCould we harvest cartilage from other animals? Such as pigs perhaps.
- scheme271 5y agoI think cadavers are the typical source. Since there's no blood vessels in it, tissue rejection isn't as much of a concern.
- vervez 5y agoThat's a strategy but there are issues with immune rejection since that's a xenograft. I think there are some products based off of this concept for other areas (skin grafts) after removing all xeno-cells from the tissue, but articular cartilage is more difficult to remove/replace xeno-cells with autologous or allogenic cells.