Have the strains been engineered with a BAC or through CRISPR-type editing or something with Cre-recombinase to get over-expression of lactase? Any out-patient

Have the strains been engineered with a BAC or through CRISPR-type editing or something with Cre-recombinase to get over-expression of lactase? Any out-patient nutritional studies showing GI intestinal biome data with positive growth conclusions?