> Israel has some great data on the combination of various number of doses and natural immunity, and the combo is very strong. https://pastebin.com/8yR3y5NA ht

> Israel has some great data on the combination of various number of doses and natural immunity, and the combo is very strong. https://pastebin.com/8yR3y5NA https://pastebin.com/8yR3y5NA The best study on this actually found no significant difference when giving a single shot to those who were naturally immune. Which makes sense because the chance of reinfection is so incredibly tiny that even if the shot completely eliminated the chance of getting COVID, the absolute size of the effect is still going to be quite small. > Additionally, the spike protein is the least likely mutation to enable escaping, as it both has to modify to be different enough from the original, plus somehow still be able to attach onto our cells with similar level of infectiousness. But you don't have to choose just one part. You could have an inactivated whole virus vaccine. That avoids the whole issue. FWIW we are already seeing point mutations on the spike developing. That's probably why Delta is so damn good at spreading, right? The Israel data suggests a VE of ~39% against Delta. I personally don't believe Pfizer's original 95% VE number, but if you do, that's a startling drop.