6 ms·

> should prove exceptionally difficult for the virus to overcome through evolutionary pressure Which is why we need gain of function experiments to accelerate

• timr 5y ago
  Gain of function experiments are not all the same. If you use an artificial selection approach (wherein selective pressure is applied to a huge library of random variations), then maybe. If you have labs picking-and-choosing what mutations to make (what usually happens), then no. That's just hubris. People stumble around in the dark, occasionally find a truffle, and pat themselves on the back for having such a great truffle-finding method. Even for good artificial selection systems, mutational space is so gigantic that it's hard to cover properly: not just the point mutations (i.e. converting one amino acid to another) but also insertions, deletions and transpositions. There's no artificial selection system I'm aware of that can recapitulate mutational space.
  • gatronicus 5y ago
    Which is why we need "intelligent design" to "help" the virus jump over this combinatorial problem. For example we can try spikes from different related viruses, or pick and choose various other tricks, like furin cleavage sites, for example like in this rejected 2018 EcoHealth coronavirus research DARPA grant proposal: https://twitter.com/JamieMetzl/status/1439989291858513929 https://twitter.com/JamieMetzl/status/1439989291858513929