I've found uwsgi is great for multiple site hosting. There are numerous ways to configure uwsgi for this purpose, one of my favorites: http://projects.unbit.it/

I've found uwsgi is great for multiple site hosting. There are numerous ways to configure uwsgi for this purpose, one of my favorites: http://projects.unbit.it/uwsgi/wiki/VirtualHosting http://projects.unbit.it/uwsgi/wiki/VirtualHosting. Newer versions of uwsgi also have a feature called emperor mode which is pretty slick: http://projects.unbit.it/uwsgi/wiki/Emperor http://projects.unbit.it/uwsgi/wiki/Emperor.