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Use of adenovirus type-5 vectored vaccines: a cautionary tale
- altrus 6y agoAdditional commentary and background can be found in Science; https://www.sciencemag.org/news/2020/10/could-certain-covid-19-vaccines-leave-people-more-vulnerable-aids-virus https://www.sciencemag.org/news/2020/10/could-certain-covid-... The concerns raised in this article do not speak to the efficacy of candidate vaccines using Ad5 vectors. Rather, they discuss the potential impact Antibody-dependent enhancement might have on at risk groups, and, as a consequence, for the design of clinical trials using those vectors.